Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 17/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18508997 | 0.91 | REN (0.55) | RENKCNH2 | |
| SCHEMBL13131658 | 0.90 | REN (0.74) | RENKCNH2 | |
| SCHEMBL18508911 | 0.88 | REN (0.57) | REN | |
| SCHEMBL18508989 | 0.86 | REN (0.59) | REN | |
| SCHEMBL18508969 | 0.85 | REN (0.70) | REN | |
| SCHEMBL18508644 | 0.84 | REN (0.83) | REN | |
| SCHEMBL13131707 | 0.83 | REN (0.70) | RENKCNH2 | |
| SCHEMBL13131740 | 0.83 | REN (0.70) | RENKCNH2 | |
| SCHEMBL18508922 | 0.82 | REN (0.63) | REN | |
| SCHEMBL13131739 | 0.81 | REN (0.67) | RENKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168952-B1 | MORPHOLINE DERIVATIVES AS RENIN INHIBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2017-02-15 | — | — | EP | disclosed |