Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT1 | P34896 | 1/20 | 0.36 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.36 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | SUCNR1 | Q9BXA5 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.34 |
| ▸ | CNR1 | P21554 | 2/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.34 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.34 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29727644 | 0.89 | L3MBTL1 (0.47) | SHMT1SHMT2AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL18285345 | 0.89 | L3MBTL1 (0.47) | SHMT1SHMT2AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL18285279 | 0.89 | CNR2 (0.45) | SHMT1SHMT2AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL29727678 | 0.89 | CNR2 (0.45) | SHMT1SHMT2AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL18512933 | 0.86 | SCN10A (0.43) | SHMT1SHMT2AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL18285294 | 0.85 | CNR1 (0.46) | SUCNR1POLBSCN10ACNR1IKBKB | |
| SCHEMBL18285292 | 0.84 | CYP1A2 (0.36) | SHMT1SHMT2AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL19641940 | 0.80 | MEN1 (0.39) | SHMT1SHMT2AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL29727624 | 0.80 | MEN1 (0.39) | SHMT1SHMT2AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL18285322 | 0.79 | SLC6A3 (0.36) | SHMT1SHMT2AKR1C4AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017025523-A1 | PYRIDINE AND PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2017-02-16 | — | — | WO | disclosed |