Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.44 |
| ▸ | YAP1 | P46937 | 1/20 | 0.44 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.44 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1851819 | 0.87 | USP30 (0.53) | ALDH1A1KDM4ETSHRHTTNPC1 | |
| SCHEMBL1850141 | 0.87 | USP30 (0.53) | ALDH1A1KDM4ETSHRHTTNPC1 | |
| SCHEMBL1855333 | 0.87 | NPSR1 (0.49) | ALDH1A1KDM4ETSHRHTTNPC1 | |
| SCHEMBL1849965 | 0.87 | NPSR1 (0.49) | ALDH1A1KDM4ETSHRHTTNPC1 | |
| SCHEMBL1854752 | 0.81 | USP30 (0.47) | ALDH1A1KDM4ETSHRHTTNPC1 | |
| SCHEMBL1851649 | 0.81 | USP30 (0.47) | ALDH1A1KDM4ETSHRHTTNPC1 | |
| SCHEMBL3343831 | 0.77 | KDM4E (0.59) | ALDH1A1KDM4ETSHRHTTNPC1 | |
| SCHEMBL3343836 | 0.77 | KDM4E (0.59) | ALDH1A1KDM4ETSHRHTTNPC1 | |
| SCHEMBL28153247 | 0.76 | LMNA (0.67) | ALDH1A1KDM4ETSHRNPC1MEN1 | |
| SCHEMBL18485519 | 0.76 | LMNA (0.67) | ALDH1A1KDM4ETSHRNPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097419-B1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | EXELIXIS INC (US) | 2011-05-25 | — | — | EP | disclosed |
| US-20090247559-A1 | Benzofuropyrimidinones | EXELIXIS, INC. (US) | 2009-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247559-A1 | Benzofuropyrimidinones | F12, BRI3BP, BRD1 | ALDH1A1 315/4885KDM4E 1855/4885TSHR 1203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.