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SCHEMBL1851695

SCHEMBL1851695

CC(C)C(C=O)N(N)c1ncc(C(N)=O)c(Nc2cccc(C#N)c2)n1

nearest known ligand 0.61

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ SYK P43405 15/20 0.61
▸ ZAP70 P43403 1/20 0.54
▸ PDE4B Q07343 3/20 0.45
▸ PDE4A P27815 1/20 0.45
▸ PDE4C Q08493 1/20 0.45
▸ PDE4D Q08499 1/20 0.45
▸ CAMK1D Q8IU85 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1353406 1.00 SYK (0.61) SYKZAP70PDE4BPDE4APDE4C
SCHEMBL1851698 0.90 SYK (0.60) SYKZAP70PDE4BPDE4APDE4C
SCHEMBL1849685 0.86 SYK (0.59) SYKCAMK1D
SCHEMBL1354628 0.86 SYK (0.59) SYKCAMK1D
SCHEMBL1853033 0.85 SYK (0.61) SYKPDE4BPDE4APDE4CPDE4D
SCHEMBL1355333 0.85 SYK (0.60) SYKCAMK1D
SCHEMBL1852547 0.85 SYK (0.60) SYKCAMK1D
SCHEMBL1352375 0.85 SYK (0.61) SYKPDE4BPDE4APDE4CPDE4D
SCHEMBL1354029 0.84 SYK (0.64) SYKZAP70CAMK1D
SCHEMBL1847521 0.83 SYK (0.62) SYKCAMK1D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2323993-A2 2,6-DIAMINO- PYRIMIDIN- 5-YL-CARBOXAMIDES AS SYK OR JAK KINASES INHIBITORS Portola Pharmaceuticals, Inc. (US) 2011-05-25 — — EP disclosed
WO-2009136995-A2 INHIBITORS OF SYK PROTEIN KINASE PORTOLA PHARMACEUTICALS, INC. (US) 2009-11-12 — — WO disclosed