Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 12/20 | 0.40 |
| ▸ | USP2 | O75604 | 5/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22230119 | 0.91 | HSD17B10 (0.45) | HSD17B10TSHRCYP2D6USP2CYP1A2 | |
| SCHEMBL18517455 | 0.90 | CYP2D6 (0.43) | HSD17B10TSHRCYP2D6USP2CYP2C9 | |
| SCHEMBL29088302 | 0.76 | TSHR (0.60) | HSD17B10TSHRCYP2D6USP2CYP1A2 | |
| SCHEMBL29418104 | 0.75 | HSD11B1 (0.42) | USP2HIF1ACYP2C19CYP3A4ALDH1A1 | |
| SCHEMBL23443978 | 0.73 | HSD17B10 (0.33) | HSD17B10CYP2D6 | |
| SCHEMBL25044367 | 0.73 | HSD17B10 (0.35) | HSD17B10TSHRCYP2D6USP2CYP1A2 | |
| SCHEMBL22230120 | 0.72 | TSHR (0.47) | HSD17B10TSHRCYP2D6USP2CYP1A2 | |
| SCHEMBL15618729 | 0.71 | HSD11B1 (0.47) | USP2HIF1ACYP2C19CYP3A4HSD11B1 | |
| SCHEMBL15140812 | 0.71 | PIK3CD (0.45) | HSD17B10USP2CYP3A4ALDH1A1ALOX15 | |
| SCHEMBL4073020 | 0.71 | HSD11B1 (0.51) | USP2HIF1ACYP2C19CYP3A4HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017027687-A1 | FUMAGILLOL SPIROCYCLIC COMPOUNDS AND FUSED BICYCLIC COMPOUNDS AND THEIR USE AS METAP2 INHIBITORS | ZAFGEN, INC. (US) | 2017-02-16 | — | — | WO | disclosed |