Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 11/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | SPR | P35270 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18517364 | 0.90 | HSD17B10 (0.41) | CYP2D6OPRM1OPRD1OPRK1HSD11B1 | |
| SCHEMBL22230119 | 0.84 | HSD17B10 (0.45) | CYP2D6OPRM1OPRD1OPRK1CYP3A4 | |
| SCHEMBL29418104 | 0.79 | HSD11B1 (0.42) | OPRM1HSD11B1CYP3A4ALDH1A1USP2 | |
| SCHEMBL28583397 | 0.76 | CYP2D6 (0.38) | CYP2D6HSD11B1CYP3A4ALDH1A1TSHR | |
| SCHEMBL4073020 | 0.75 | HSD11B1 (0.51) | HSD11B1CYP3A4USP2SPR | |
| SCHEMBL15140812 | 0.75 | PIK3CD (0.45) | OPRM1OPRD1OPRK1CYP3A4ALDH1A1 | |
| SCHEMBL15618729 | 0.75 | HSD11B1 (0.47) | HSD11B1CYP3A4USP2SPR | |
| SCHEMBL4066199 | 0.74 | HSD11B1 (0.54) | HSD11B1CYP3A4USP2SPR | |
| Hydrochloric Acid SCHEMBL30751767 | 0.74 | HSD11B1 (0.46) | HSD11B1CYP3A4USP2SPR | |
| SCHEMBL18497966 | 0.73 | OPRM1 (0.32) | OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017027687-A1 | FUMAGILLOL SPIROCYCLIC COMPOUNDS AND FUSED BICYCLIC COMPOUNDS AND THEIR USE AS METAP2 INHIBITORS | ZAFGEN, INC. (US) | 2017-02-16 | — | — | WO | disclosed |