Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 6/20 | 0.46 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.41 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.41 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.39 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18517590 | 0.90 | GRIN2B (0.55) | GRIN2BS1PR5S1PR1PLA2G10PLA2G5 | |
| SCHEMBL10063608 | 0.76 | ALDH1A1 (0.57) | ATM | |
| SCHEMBL649847 | 0.75 | KCNK3 (0.55) | GRIN2BS1PR5S1PR1KCNK3KCNK9 | |
| SCHEMBL16053284 | 0.75 | KCNK3 (0.55) | GRIN2BS1PR5S1PR1KCNK3KCNK9 | |
| SCHEMBL584450 | 0.75 | KCNK3 (0.55) | GRIN2BS1PR5S1PR1KCNK3KCNK9 | |
| SCHEMBL18498285 | 0.74 | GRIN2B (0.49) | GRIN2BS1PR5S1PR1 | |
| Hydrochloric Acid SCHEMBL6093599 | 0.74 | KCNK3 (0.54) | GRIN2BS1PR5S1PR1KCNK3KCNK9 | |
| Hydrochloric Acid SCHEMBL6095348 | 0.74 | KCNK3 (0.54) | GRIN2BS1PR5S1PR1KCNK3KCNK9 | |
| SCHEMBL3395200 | 0.73 | GRIN2B (0.47) | GRIN2BS1PR5S1PR1KCNK3KCNK9 | |
| SCHEMBL19971639 | 0.72 | GRIN2B (0.40) | GRIN2BS1PR5S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017027687-A1 | FUMAGILLOL SPIROCYCLIC COMPOUNDS AND FUSED BICYCLIC COMPOUNDS AND THEIR USE AS METAP2 INHIBITORS | ZAFGEN, INC. (US) | 2017-02-16 | — | — | WO | disclosed |