Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24127481 | 1.00 | HSD17B10 (0.39) | HSD17B10MAPTHRH4HRH3MEN1 | |
| SCHEMBL24688969 | 0.87 | HSD17B10 (0.41) | HSD17B10MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL18498210 | 0.83 | HSD17B10 (0.39) | HSD17B10MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL18498287 | 0.83 | HSD17B10 (0.39) | HSD17B10MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3314634 | 0.79 | MAPT (0.41) | HSD17B10MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL23325422 | 0.79 | HSD17B10 (0.41) | HSD17B10MAPTHRH4MEN1KMT2A | |
| SCHEMBL24127487 | 0.77 | HSD17B10 (0.37) | HSD17B10MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2744311 | 0.77 | DPP4 (0.40) | HSD17B10MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL18498161 | 0.77 | CHRNB2 (0.61) | — | |
| SCHEMBL6757495 | 0.77 | DPP4 (0.40) | HSD17B10MAPTMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017027687-A1 | FUMAGILLOL SPIROCYCLIC COMPOUNDS AND FUSED BICYCLIC COMPOUNDS AND THEIR USE AS METAP2 INHIBITORS | ZAFGEN, INC. (US) | 2017-02-16 | — | — | WO | disclosed |