Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18498598 | 1.00 | HDAC4 (0.32) | HDAC4HTR2CHTR2B | |
| SCHEMBL12690280 | 0.88 | BACE1 (0.35) | — | |
| SCHEMBL12690003 | 0.88 | BACE1 (0.35) | — | |
| SCHEMBL13177584 | 0.88 | BACE1 (0.35) | — | |
| SCHEMBL2619829 | 0.88 | BACE1 (0.35) | — | |
| SCHEMBL3300585 | 0.76 | BACE1 (0.45) | — | |
| SCHEMBL7925283 | 0.76 | BACE1 (0.45) | — | |
| SCHEMBL932759 | 0.75 | BACE1 (0.35) | — | |
| SCHEMBL6877967 | 0.75 | BACE1 (0.35) | — | |
| SCHEMBL12690183 | 0.75 | BACE1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017025565-A1 | 2-AMINO-7A-PHENYL-3,4,4A,5,7,7A-HEXAHYDROFURO[3,4-B]PYRIDINES AS BACE1 INHIBITORS | H. LUNDBECK A/S (DK) | 2017-02-16 | — | — | WO | disclosed |