Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR52 | Q9Y2T5 | 4/20 | 0.53 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 2/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3217370 | 0.96 | GPR52 (0.56) | GPR52CLK1METAP2SHMT1PARP1 | |
| SCHEMBL1849783 | 0.95 | GPR52 (0.56) | GPR52PLA2G2ARXRARXRBPTGER1 | |
| SCHEMBL1855888 | 0.94 | GPR52 (0.52) | GPR52PLA2G2ACLK1METAP2RXRA | |
| SCHEMBL3206698 | 0.90 | GPR52 (0.55) | GPR52CLK1METAP2SHMT1PARP1 | |
| SCHEMBL1852756 | 0.89 | GPR52 (0.56) | GPR52PLA2G2ARXRARXRBPTGER1 | |
| SCHEMBL1851979 | 0.87 | GPR52 (0.53) | GPR52PTGER1AKR1C3AKR1C2NPC1 | |
| SCHEMBL1851422 | 0.86 | GPR52 (0.49) | GPR52RXRARXRBPTGER1AKR1C3 | |
| SCHEMBL3209104 | 0.85 | GPR52 (0.72) | GPR52CLK1METAP2 | |
| SCHEMBL13489633 | 0.84 | GPR52 (0.46) | GPR52METAP2PARP1 | |
| SCHEMBL1849572 | 0.84 | GPR52 (0.71) | GPR52RXRARXRBPTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323978-A1 | AMIDE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010018874-A1 | AMIDE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-02-18 | — | — | WO | disclosed |