SCHEMBL1851970

SCHEMBL1851970

COCCNC(=O)c1cccc(-c2cccc3c(C)c(Cc4cccc(C(F)(F)F)c4)sc23)c1.Cc1c(Cc2cccc(C(F)(F)F)c2)sc2c(-c3cccc(C(=O)O)c3)cccc12

nearest known ligand 0.67

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GPR52 Q9Y2T5 19/20 0.67
MRGPRX4 Q96LA9 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3211211 0.97 GPR52 (0.71) GPR52MRGPRX4
SCHEMBL3204204 0.90 GPR52 (0.61) GPR52
SCHEMBL1850602 0.89 GPR52 (0.49) GPR52MRGPRX4
SCHEMBL3209929 0.89 GPR52 (0.60) GPR52
SCHEMBL3210910 0.89 GPR52 (0.71) GPR52MRGPRX4
SCHEMBL1849415 0.89 GPR52 (0.69) GPR52
SCHEMBL1852132 0.88 GPR52 (0.59) GPR52MRGPRX4
SCHEMBL3204533 0.86 GPR52 (0.56) GPR52
SCHEMBL1856519 0.85 GPR52 (0.65) GPR52MRGPRX4
SCHEMBL1852205 0.85 GPR52 (0.47) GPR52MRGPRX4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2323978-A1 AMIDE COMPOUND Takeda Pharmaceutical Company Limited (JP) 2011-05-25 EP disclosed
WO-2010018874-A1 AMIDE COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-02-18 WO disclosed