Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 9/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 5/20 | 0.41 |
| ▸ | ADK | P55263 | 5/20 | 0.41 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GALR3 | O60755 | 1/20 | 0.41 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 3/20 | 0.40 |
| ▸ | EGFR | P00533 | 3/20 | 0.40 |
| ▸ | ABL2 | P42684 | 3/20 | 0.40 |
| ▸ | METTL3 | Q86U44 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17106775 | 0.87 | PRMT5 (0.40) | CA2PRMT5WDR77ADKDOT1L | |
| SCHEMBL17131291 | 0.86 | ADK (0.43) | CA2PRMT5WDR77ADKDOT1L | |
| SCHEMBL18490333 | 0.85 | ADK (0.52) | CA2PRMT5ADKDOT1LNPC1 | |
| SCHEMBL17106858 | 0.85 | ADK (0.52) | CA2PRMT5ADKDOT1LNPC1 | |
| SCHEMBL16360128 | 0.80 | ADA (0.57) | DOT1LHTTEGFR | |
| SCHEMBL15832423 | 0.80 | ADA (0.57) | DOT1LHTTEGFR | |
| SCHEMBL10432419 | 0.80 | ADA (0.57) | DOT1LHTTEGFR | |
| SCHEMBL17131292 | 0.78 | ADK (0.45) | CA2PRMT5WDR77ADKMETTL3 | |
| SCHEMBL25948798 | 0.78 | PRMT5 (0.49) | PRMT5ADKDOT1LMETTL3 | |
| SCHEMBL17106721 | 0.77 | PRMT5 (0.38) | CA2PRMT5WDR77ADKMETTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017027646-A1 | CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2017-02-16 | — | — | WO | disclosed |