Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 3/20 | 0.49 |
| ▸ | ADK | P55263 | 6/20 | 0.48 |
| ▸ | METTL3 | Q86U44 | 11/20 | 0.48 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.40 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17106819 | 0.88 | PRMT5 (0.48) | PRMT5ADKMETTL3RAPGEF3 | |
| SCHEMBL17131312 | 0.83 | ADK (0.55) | PRMT5ADKMETTL3RAPGEF3DOT1L | |
| SCHEMBL24313576 | 0.81 | PRMT5 (0.59) | PRMT5ADKMETTL3 | |
| SCHEMBL17106776 | 0.81 | PRMT5 (0.59) | PRMT5ADKMETTL3 | |
| SCHEMBL20419182 | 0.81 | PRMT5 (0.59) | PRMT5ADKMETTL3 | |
| SCHEMBL18314959 | 0.81 | ADA (0.53) | DOT1L | |
| SCHEMBL22143020 | 0.81 | ADA (0.53) | DOT1L | |
| SCHEMBL17106775 | 0.78 | PRMT5 (0.40) | PRMT5ADKMETTL3DOT1L | |
| SCHEMBL18519982 | 0.78 | CA2 (0.41) | PRMT5ADKMETTL3DOT1L | |
| SCHEMBL17106864 | 0.77 | PRMT5 (0.47) | PRMT5ADKMETTL3RAPGEF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219496-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN Pharmaceutica NV (BE) | 2023-08-02 | — | — | EP | disclosed |