Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 4/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | PTGFR | P43088 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18520684 | 0.85 | KMT2A (0.37) | KMT2APDE2APDE10APOLBPLA2G7 | |
| SCHEMBL18520289 | 0.81 | CCNB2 (0.42) | KMT2AKDM4EALDH1A1GLAPDE2A | |
| SCHEMBL18520686 | 0.78 | BRAF (0.36) | KMT2APDE2APDE10APOLBPLA2G7 | |
| SCHEMBL18520727 | 0.78 | PDE2A (0.43) | KMT2AKDM4EALDH1A1PDE2APDE10A | |
| SCHEMBL18520594 | 0.69 | ALDH1A1 (0.40) | KMT2AKDM4EALDH1A1PDE2APDE10A | |
| SCHEMBL18520288 | 0.69 | ALDH1A1 (0.40) | KMT2AKDM4EALDH1A1PDE2APDE10A | |
| SCHEMBL18520592 | 0.67 | GRM2 (0.40) | KMT2AALDH1A1GRM2LMNASMN1; SMN2 | |
| SCHEMBL18520682 | 0.67 | CCNB2 (0.36) | KMT2AKDM4EALDH1A1PDE2APDE10A | |
| SCHEMBL18520513 | 0.67 | ALDH1A1 (0.38) | KMT2AALDH1A1PDE2APDE10ALMNA | |
| SCHEMBL6588868 | 0.63 | HSP90AA1 (0.47) | KMT2AKDM4EALDH1A1GLALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017027768-A1 | COMPOSITIONS AND METHODS FOR TREATING TUBERCULOSIS | THE BROAD INSTITUTE, INC. (US) | 2017-02-16 | — | — | WO | disclosed |