Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 3/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | GUSB | P08236 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18520683 | 0.85 | KMT2A (0.39) | KMT2APOLBPLA2G7PDE2APDE10A | |
| SCHEMBL18520686 | 0.79 | BRAF (0.36) | KMT2APOLBPLA2G7PDE2APDE10A | |
| SCHEMBL18520727 | 0.77 | PDE2A (0.43) | KMT2APOLBPDE2APDE10ASMN1; SMN2 | |
| SCHEMBL18520288 | 0.68 | ALDH1A1 (0.40) | KMT2APOLBPLA2G7PDE2APDE10A | |
| SCHEMBL18520594 | 0.68 | ALDH1A1 (0.40) | KMT2APOLBPLA2G7PDE2APDE10A | |
| SCHEMBL18520289 | 0.67 | CCNB2 (0.42) | KMT2APOLBPLA2G7PDE2APDE10A | |
| SCHEMBL18520287 | 0.66 | BACE1 (0.40) | KMT2APOLBPLA2G7PDE2APDE10A | |
| SCHEMBL18520513 | 0.65 | ALDH1A1 (0.38) | KMT2APDE2APDE10ASMN1; SMN2LMNA | |
| SCHEMBL18520750 | 0.63 | CHEK1 (0.43) | KMT2ASMN1; SMN2GSK3BGAA | |
| SCHEMBL29294775 | 0.62 | PLA2G7 (0.64) | KMT2APOLBPLA2G7HSD11B1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017027768-A1 | COMPOSITIONS AND METHODS FOR TREATING TUBERCULOSIS | THE BROAD INSTITUTE, INC. (US) | 2017-02-16 | — | — | WO | disclosed |