Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | JMJD6 | Q6NYC1 | 2/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | NNMT | P40261 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | MLYCD | O95822 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18501528 | 0.87 | TDP2 (0.41) | TDP2LMNATHRBHTTJMJD6 | |
| SCHEMBL18490201 | 0.86 | TDP2 (0.40) | TDP2LMNATHRBHTTJMJD6 | |
| SCHEMBL18511704 | 0.85 | TDP2 (0.40) | TDP2LMNATHRBHTTJMJD6 | |
| SCHEMBL18490255 | 0.82 | TDP2 (0.37) | TDP2LMNATHRBHTTJMJD6 | |
| SCHEMBL18490194 | 0.79 | TDP2 (0.39) | TDP2LMNAHTTALDH1A1L3MBTL1 | |
| SCHEMBL18492272 | 0.79 | TDP2 (0.37) | TDP2LMNATHRBHTTFFAR4 | |
| SCHEMBL18490152 | 0.68 | PRKCZ (0.43) | TDP2HTTALDH1A1NPC1KDM4E | |
| SCHEMBL18490109 | 0.67 | EED (0.40) | TDP2LMNATHRBALDH1A1KDM4E | |
| SCHEMBL18501529 | 0.67 | TDP2 (0.41) | TDP2LMNATHRBHTTALDH1A1 | |
| SCHEMBL18501532 | 0.66 | TDP2 (0.42) | TDP2LMNATHRBHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017027310-A1 | GPR40 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES | JANSSEN PHARMACEUTICA NV (BE) | 2017-02-16 | — | — | WO | disclosed |