SCHEMBL18522668

SCHEMBL18522668

CC(=O)N(C)C(=O)CCC=O

nearest known ligand 0.36

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
HPGD P15428 1/20 0.36
MAPT P10636 1/20 0.33
PHF8 Q9UPP1 1/20 0.32
KDM2A Q9Y2K7 1/20 0.32
ALDH1A1 P00352 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4721832 0.78
SCHEMBL22908271 0.77 MEN1 (0.32) MAPT
SCHEMBL5664501 0.76
SCHEMBL18656542 0.74
SCHEMBL26250211 0.74
SCHEMBL19192933 0.74
SCHEMBL19083864 0.74 MAPT (0.35) HPGDMAPTPHF8KDM2AALDH1A1
SCHEMBL7664482 0.73 ALDH1A1 (0.36) HPGDMAPTPHF8KDM2AALDH1A1
SCHEMBL22375822 0.72 EPHX2 (0.35) HPGDALDH1A1
SCHEMBL12729851 0.72 HPGD (0.33) HPGDMAPTPHF8KDM2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3604386-A1 DEGRADABLE POLYETHYLENE GLYCOL DERIVATIVE HAVING DISULFIDE LINKER NOF Corporation (JP) 2020-02-05 EP disclosed
EP-3279236-A1 BIODEGRADABLE POLYETHYLENE GLYCOL DERIVATIVE HAVING CYCLIC BENZYLIDENE ACETAL LINKER NOF Corporation (JP) 2018-02-07 EP disclosed
EP-3130587-A1 HYDROPHILIC POLYMER DERIVATIVE HAVING CYCLIC BENZYLIDENE ACETAL LINKER NOF Corporation (JP) 2017-02-15 EP disclosed