SCHEMBL18524399

SCHEMBL18524399

Fc1ccc(Br)c2c1CNCC2

nearest known ligand 0.41

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
HTR2C P28335 5/20 0.41
HTR2A P28223 3/20 0.41
HTR2B P41595 3/20 0.41
PNMT P11086 6/20 0.40
NISCH Q9Y2I1 1/20 0.39
ASIC3 Q9UHC3 1/20 0.35
ADRA2A P08913 1/20 0.34
ADRA2B P18089 1/20 0.34
ADRA2C P18825 1/20 0.34
CD44 P16070 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30031884 1.00 HTR2C (0.41) HTR2CHTR2AHTR2BPNMTNISCH
SCHEMBL15056295 0.92 HTR2C (0.41) HTR2CHTR2AHTR2BPNMTNISCH
Hydrochloric Acid SCHEMBL15055802 0.91 HTR2C (0.40) HTR2CHTR2AHTR2BPNMTNISCH
SCHEMBL2258843 0.86 HTR2C (0.47) HTR2CHTR2AHTR2BPNMTNISCH
Hydrochloric Acid SCHEMBL1198541 0.84 HTR2C (0.46) HTR2CHTR2AHTR2BPNMTNISCH
Hydrochloric Acid SCHEMBL20608483 0.82 ABCC9 (0.33) HTR2CHTR2AHTR2B
SCHEMBL38664536 0.77 PNMT (0.50) HTR2CHTR2AHTR2BPNMTNISCH
SCHEMBL9202498 0.77 CD44 (0.50) HTR2CHTR2AHTR2BPNMTNISCH
SCHEMBL30396027 0.77 HTR2C (0.41) HTR2CHTR2AHTR2BPNMTNISCH
SCHEMBL3146223 0.77 NISCH (0.42) HTR2CHTR2AHTR2BPNMTNISCH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250084081-A1 COMPOUNDS FOR TARGETED DEGRADATION OF BRD9 C4 THERAPEUTICS, INC. (US) 2025-03-13 US disclosed
US-12157735-B2 Compounds for targeted degradation of BRD9 C4 THERAPEUTICS, INC. (US) 2024-12-03 US disclosed
US-12049464-B2 Compounds for targeted degradation of BRD9 C4 THERAPEUTICS, INC. (US) 2024-07-30 US disclosed
US-20240051953-A1 COMPOUNDS FOR TARGETED DEGRADATION OF BRD9 C4 THERAPEUTICS, INC. (US) 2024-02-15 US disclosed
US-11691972-B2 Compounds for targeted degradation of BRD9 C4 THERAPEUTICS, INC. (US) 2023-07-04 US disclosed
US-11691972-B2 Compounds for targeted degradation of BRD9 C4 THERAPEUTICS, INC. (US) 2023-07-04 US disclosed
US-11691972-B2 Compounds for targeted degradation of BRD9 C4 THERAPEUTICS, INC. (US) 2023-07-04 US disclosed
US-20230060334-A1 COMPOUNDS FOR TARGETED DEGRADATION OF BRD9 C4 THERAPEUTICS, INC. (US) 2023-03-02 US disclosed
EP-4114392-A1 COMPOUNDS FOR TARGETED DEGRADATION OF BRD9 C4 Therapeutics, Inc. (US) 2023-01-11 EP disclosed
CN-115279370-A Compounds for targeted degradation of BRD9 C4医药公司 2022-11-01 CN disclosed
US-20220098194-A1 COMPOUNDS FOR TARGETED DEGRADATION OF BRD9 C4 THERAPEUTICS, INC. (US) 2022-03-31 US disclosed
WO-2021178920-A1 COMPOUNDS FOR TARGETED DEGRADATION OF BRD9 C4 THERAPEUTICS, INC. (US) 2021-09-10 WO disclosed
WO-2021178920-A1 COMPOUNDS FOR TARGETED DEGRADATION OF BRD9 C4 THERAPEUTICS, INC. (US) 2021-09-10 WO disclosed
EP-2794563-B1 HETEROCYCLYL DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS ACTELION PHARMACEUTICALS LTD (CH) 2017-02-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230060334-A1 COMPOUNDS FOR TARGETED DEGRADATION OF BRD9 BRD9, BRD1, BRWD1 HTR2C 4387/4885HTR2A 4176/4885HTR2B 4331/4885
US-20220098194-A1 COMPOUNDS FOR TARGETED DEGRADATION OF BRD9 BRD9, BRD1, BRWD1 HTR2C 4387/4885HTR2A 4176/4885HTR2B 4331/4885
US-12157735-B2 Compounds for targeted degradation of BRD9 BRD9, BRD1, BRWD1 HTR2C 4387/4885HTR2A 4176/4885HTR2B 4331/4885
US-12049464-B2 Compounds for targeted degradation of BRD9 BRD9, BRD1, BRWD1 HTR2C 4387/4885HTR2A 4176/4885HTR2B 4331/4885
US-20240051953-A1 COMPOUNDS FOR TARGETED DEGRADATION OF BRD9 BRD9, BRD1, BRWD1 HTR2C 4387/4885HTR2A 4176/4885HTR2B 4331/4885
US-20250084081-A1 COMPOUNDS FOR TARGETED DEGRADATION OF BRD9 BRD9, BRD1, BRWD1 HTR2C 4387/4885HTR2A 4176/4885HTR2B 4331/4885
US-11691972-B2 Compounds for targeted degradation of BRD9 BRD9, BRD1, BRWD1 HTR2C 4269/4885HTR2A 4061/4885HTR2B 4353/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.