Glyhexamide

Glyhexamide

SCHEMBL185244

O=C(NC1CCCCC1)NS(=O)(=O)c1ccc2c(c1)CCC2

nearest known ligand 0.64

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 1/20 0.64
ALDH1A1 P00352 7/20 0.61
TDP1 Q9NUW8 2/20 0.61
LMNA P02545 1/20 0.61
THRB P10828 1/20 0.61
TSHR P16473 1/20 0.61
BLM P54132 1/20 0.61
HSD11B1 P28845 1/20 0.52
PPARG P37231 3/20 0.52
HRH3 Q9Y5N1 3/20 0.50
CYP2C9 P11712 2/20 0.48
CYP2C19 P33261 2/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
KDM4E B2RXH2 1/20 0.48
POLB P06746 1/20 0.46
GAA P10253 3/20 0.46
MEN1 O00255 1/20 0.46
KMT2A Q03164 1/20 0.46
KCNH2 Q12809 1/20 0.46
CYP3A4 P08684 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Glyhexamide SCHEMBL27491055 1.00 ADORA3 (0.64) ADORA3ALDH1A1TDP1LMNATHRB
SCHEMBL11763585 0.86 ADORA3 (0.54) ADORA3ALDH1A1TDP1LMNATHRB
SCHEMBL11765186 0.86 ADORA3 (0.54) ADORA3ALDH1A1TDP1LMNATHRB
SCHEMBL11764729 0.84 ADORA3 (0.55) ADORA3ALDH1A1TDP1LMNATHRB
SCHEMBL11761600 0.83 ADORA3 (0.54) ADORA3ALDH1A1TDP1LMNATHRB
SCHEMBL11760402 0.83 ADORA3 (0.54) ADORA3ALDH1A1TDP1LMNATHRB
SCHEMBL11766631 0.83 ADORA3 (0.54) ADORA3ALDH1A1TDP1LMNATHRB
SCHEMBL11761408 0.83 ADORA3 (0.50) ADORA3ALDH1A1TDP1LMNATHRB
SCHEMBL11766694 0.82 ADORA3 (0.52) ADORA3ALDH1A1TDP1LMNATHRB
SCHEMBL11764027 0.82 ADORA3 (0.52) ADORA3ALDH1A1TDP1LMNATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2809 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12208071-B2 Glucagon receptor antagonists LIGAND PHARMACEUTICALS INCORPORATED (US) 2025-01-28 US claimed
US-12186329-B2 Compositions and methods related to cholic acid 7-sulfate as a treatment for diabetes PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2025-01-07 US claimed
US-20240316048-A1 Prevention of Pancreatic Cell Degeneration MELIOR PHARMACEUTICALS I, INC. 2024-09-26 US claimed
US-12070461-B2 Methods and formulations for modulating Lyn kinase activity and treating related disorders MELIOR PHARMACEUTICALS I, INC. (US) 2024-08-27 US claimed
US-20230263821-A1 Treatment Of Increased Lipid Levels With Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) Inhibitors UNIVERSITY OF MARYLAND, BALTIMORE 2023-08-24 US claimed
EP-1931320-B1 MICROPARTICLES WITH MODIFIED RELEASE OF AT LEAST ONE ACTIVE PRINCIPLE AND ORAL DOSAGE FORM COMPRISING THE SAME FLAMEL IRELAND LTD (IE) 2022-06-15 EP claimed
US-20210361652-A1 Methods And Formulations For Modulating Lyn Kinase Activity And Treating Related Disorders MELIOR PHARMACEUTICALS I, INC. 2021-11-25 US claimed
US-20210315908-A1 COMPOSITIONS AND METHODS RELATED TO CHOLIC ACID 7-SULFATE AS A TREATMENT FOR DIABETES PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2021-10-14 US claimed
CN-113423404-A Xanthine derivative pharmaceutical composition and preparation method thereof 成都苑东生物制药股份有限公司 2021-09-21 CN claimed
EP-1931350-B2 ADMINISTRATION OF DIPEPTIDYL PEPTIDASE INHIBITORS TAKEDA PHARMACEUTICALS CO (JP) 2021-08-04 EP claimed
EP-1073470-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2001-02-07 EP claimed
US-6150383-A COMPRISING AN INSULIN SENSITIVITY ENHANCER IN COMBINATION WITH ONE OR MORE OTHER ANTIDIABETICS DIFFERING FROM THE ENHANCER IN MECHANISM OF ACTION; LIPID/GLYCOMETABOLISM DISORDERS; ANTIDIABETIC AGENTS; SIDE EFFECT REDUCTION TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2000-11-21 US claimed
WO-2000048636-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2000-08-24 WO claimed
WO-2000027401-A1 COMBINATIONS FOR DIABETES WHICH CONTAIN A SULFONYLUREA, A GLITAZONE AND A BIGUANIDE WARNER-LAMBERT COMPANY (US) 2000-05-18 WO claimed
CN-1244801-A Sulfonylurea-glitazone synergistic combinations for diabetes WARNER LAMBERT CO (US) 2000-02-16 CN claimed
US-6011049-A Combinations for diabetes WARNER-LAMBERT COMPANY (US) 2000-01-04 US claimed
EP-0957923-A1 SULFONYLUREA-GLITAZONE SYNERGISTIC COMBINATIONS FOR DIABETES WARNER-LAMBERT COMPANY (US) 1999-11-24 EP claimed
US-5972973-A SYNERGISTIC MIXTURE; GLUCOSE CONTROL WARNER-LAMBERT COMPANY (US) 1999-10-26 US claimed
US-5859037-A MIXTURE SYNERGISTIC FOR THE TREATMENT OF NON-INSULIN DEPENDENT DIABETES MELLITUS IN HUMANS, WHICH ALSO IMPROVES GLYCEMIC CONTROL WARNER-LAMBERT COMPANY (US) 1999-01-12 US claimed
WO-1998036755-A1 SULFONYLUREA-GLITAZONE SYNERGISTIC COMBINATIONS FOR DIABETES WARNER LAMBERT COMPANY (US) 1998-08-27 WO claimed