Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | KCNA1 | Q09470 | 5/20 | 0.44 |
| ▸ | KCNAB1 | Q14722 | 5/20 | 0.44 |
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11765186 | 1.00 | ADORA3 (0.54) | ADORA3ALDH1A1LMNATHRBTSHR | |
| SCHEMBL11761408 | 0.92 | ADORA3 (0.50) | ADORA3ALDH1A1LMNATHRBTSHR | |
| SCHEMBL11759176 | 0.89 | ADORA3 (0.47) | ADORA3ALDH1A1LMNATHRBTSHR | |
| SCHEMBL11764729 | 0.87 | ADORA3 (0.55) | ADORA3ALDH1A1LMNATHRBTSHR | |
| SCHEMBL11764048 | 0.87 | KCNA1 (0.41) | ADORA3ALDH1A1LMNATHRBTSHR | |
| SCHEMBL11761600 | 0.86 | ADORA3 (0.54) | ADORA3ALDH1A1LMNATHRBTSHR | |
| SCHEMBL11766631 | 0.86 | ADORA3 (0.54) | ADORA3ALDH1A1LMNATHRBTSHR | |
| SCHEMBL11760402 | 0.86 | ADORA3 (0.54) | ADORA3ALDH1A1LMNATHRBTSHR | |
| Glyhexamide SCHEMBL185244 | 0.86 | ADORA3 (0.64) | ADORA3ALDH1A1LMNATHRBTSHR | |
| Glyhexamide SCHEMBL27491055 | 0.86 | ADORA3 (0.64) | ADORA3ALDH1A1LMNATHRBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4024128-A | HYPOGLYCEMIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1977-05-17 | — | — | US | claimed |
| US-4024128-A | HYPOGLYCEMIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1977-05-17 | — | — | US | disclosed |