Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 13/20 | 0.42 |
| ▸ | JAK2 | O60674 | 12/20 | 0.42 |
| ▸ | JAK1 | P23458 | 8/20 | 0.42 |
| ▸ | TYK2 | P29597 | 4/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.38 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20183292 | 0.81 | ALDH1A1 (0.42) | ALDH1A1MEN1MAPTKMT2AJAK3 | |
| SCHEMBL12957767 | 0.81 | ALDH1A1 (0.63) | CHRM2CHRM4CHRM1CHRM3ALDH1A1 | |
| SCHEMBL13724137 | 0.81 | JAK3 (0.44) | ALDH1A1MEN1MAPTKMT2AJAK3 | |
| SCHEMBL14644693 | 0.81 | ALDH1A1 (0.63) | CHRM2CHRM4CHRM1CHRM3ALDH1A1 | |
| SCHEMBL14426034 | 0.81 | ALDH1A1 (0.63) | CHRM2CHRM4CHRM1CHRM3ALDH1A1 | |
| SCHEMBL22620113 | 0.81 | JAK3 (0.44) | ALDH1A1MEN1MAPTKMT2AJAK3 | |
| SCHEMBL1899294 | 0.81 | ALDH1A1 (0.38) | ALDH1A1MEN1MAPTKMT2AJAK3 | |
| SCHEMBL22370793 | 0.80 | JAK2 (0.47) | CHRM2CHRM4CHRM1CHRM3ALDH1A1 | |
| SCHEMBL22370790 | 0.80 | JAK2 (0.47) | CHRM2CHRM4CHRM1CHRM3ALDH1A1 | |
| SCHEMBL27266866 | 0.80 | ALDH1A1 (0.50) | CA12CA1CA2CA9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017025849-A1 | BICYCLIC-FUSED HETEROARYL OR ARYL COMPOUNDS | PFIZER INC. (US) | 2017-02-16 | — | — | WO | disclosed |