Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 15/20 | 0.44 |
| ▸ | JAK2 | O60674 | 14/20 | 0.44 |
| ▸ | JAK1 | P23458 | 9/20 | 0.44 |
| ▸ | KDM1A | O60341 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 6/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | MARK3 | P27448 | 2/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.39 |
| ▸ | STK3 | Q13188 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.39 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.39 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.39 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13724137 | 1.00 | JAK3 (0.44) | JAK3JAK2JAK1KDM1AALDH1A1 | |
| SCHEMBL19014106 | 0.82 | MCL1 (0.39) | JAK3JAK2JAK1KDM1AALDH1A1 | |
| SCHEMBL18525632 | 0.81 | CHRM2 (0.44) | JAK3JAK2JAK1ALDH1A1MEN1 | |
| SCHEMBL20183292 | 0.80 | ALDH1A1 (0.42) | JAK3JAK2JAK1ALDH1A1MEN1 | |
| SCHEMBL12957767 | 0.80 | ALDH1A1 (0.63) | ALDH1A1MEN1MAPTKMT2ALMNA | |
| SCHEMBL14644693 | 0.80 | ALDH1A1 (0.63) | ALDH1A1MEN1MAPTKMT2ALMNA | |
| SCHEMBL14426034 | 0.80 | ALDH1A1 (0.63) | ALDH1A1MEN1MAPTKMT2ALMNA | |
| SCHEMBL3428769 | 0.79 | ALDH1A1 (0.43) | JAK3JAK2JAK1KDM1AALDH1A1 | |
| SCHEMBL13723895 | 0.79 | GNAI3 (0.47) | JAK3JAK2JAK1KDM1AALDH1A1 | |
| SCHEMBL22370793 | 0.79 | JAK2 (0.47) | JAK3JAK2JAK1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020223728-A1 | SUBSTITUTED PYRROLOPYRIDINES AS JAK INHIBITORS | ACLARIS THERAPEUTICS, INC. (US) | 2020-11-05 | — | — | WO | disclosed |