Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | KDM5A | P29375 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | PLAT | P00750 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18497724 | 0.83 | MAPT (0.45) | KDM4EMCL1PARP1PARP10PTGER1 | |
| SCHEMBL1893519 | 0.81 | EGFR (0.46) | KDM4EMCL1CNR1EGFR | |
| SCHEMBL30786373 | 0.81 | EGFR (0.46) | KDM4EMCL1CNR1EGFR | |
| SCHEMBL1896473 | 0.81 | EGFR (0.47) | KDM4EMCL1KDM5AKDM4CKDM5B | |
| SCHEMBL1893310 | 0.81 | KMT2A (0.47) | KDM4EMCL1PTGER1CNR1EGFR | |
| SCHEMBL6004853 | 0.80 | IRAK4 (0.53) | KDM4EIRAK4RET | |
| SCHEMBL1894250 | 0.79 | KDR (0.52) | EGFRRET | |
| SCHEMBL22965528 | 0.79 | TDP1 (0.43) | KDM4EMCL1PLAUEGFRIRAK4 | |
| SCHEMBL1895466 | 0.79 | NMT1 (0.49) | MCL1CNR1EGFR | |
| SCHEMBL21805911 | 0.78 | EGFR (0.49) | KDM4EEGFRIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017025849-A1 | BICYCLIC-FUSED HETEROARYL OR ARYL COMPOUNDS | PFIZER INC. (US) | 2017-02-16 | — | — | WO | disclosed |