Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.32 |
| ▸ | ACHE | P22303 | 5/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1196482 | 0.77 | ACHE (0.44) | ACHE | |
| SCHEMBL17467920 | 0.77 | JAK2 (0.35) | JAK2JAK1TYK2JAK3CD274 | |
| SCHEMBL9921839 | 0.76 | JAK2 (0.41) | JAK2JAK1TYK2JAK3CD274 | |
| SCHEMBL1343572 | 0.75 | JAK2 (0.41) | JAK2JAK1TYK2JAK3CD274 | |
| SCHEMBL9918386 | 0.75 | JAK2 (0.43) | JAK2JAK1TYK2JAK3CD274 | |
| SCHEMBL17459842 | 0.75 | JAK2 (0.41) | JAK2JAK1TYK2JAK3CD274 | |
| SCHEMBL1300155 | 0.75 | JAK2 (0.41) | JAK2JAK1TYK2JAK3CD274 | |
| SCHEMBL19790155 | 0.75 | JAK2 (0.41) | JAK2JAK1TYK2JAK3CD274 | |
| SCHEMBL1344395 | 0.74 | CYP11B2 (0.36) | JAK2JAK1TYK2JAK3CD274 | |
| SCHEMBL1344391 | 0.74 | CYP11B2 (0.36) | JAK2JAK1TYK2JAK3CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3337787-A1 | PYRAZOLO FUSED HETEROCYCLIC COMPOUNDS AS ERK INHIBITORS | Changzhou Jiekai Pharmatech Co. Ltd. (CN) | 2018-06-27 | — | — | EP | disclosed |
| WO-2017028314-A1 | PYRAZOLO FUSED HETEROCYCLIC COMPOUNDS AS ERK INHIBITORS | CHANGZHOU JIEKAI PHARMATECH CO., LTD. (CN) | 2017-02-23 | — | — | WO | disclosed |