Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.63 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.61 |
| ▸ | ACP1 | P24666 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | STAT1 | P42224 | 1/20 | 0.57 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.57 |
| ▸ | CDK2 | P24941 | 1/20 | 0.56 |
| ▸ | GSK3A | P49840 | 1/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.56 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4909104 | 0.84 | CXCR2 (0.76) | MAPTDYRK1ASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL6068032 | 0.84 | KMT2A (0.74) | MAPTDYRK1ASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL5001543 | 0.84 | RIPK1 (0.63) | MAPTDYRK1ASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL17287743 | 0.83 | MAPT (0.76) | MAPTDYRK1ASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL18541791 | 0.82 | LCK (0.62) | MAPTDYRK1ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL18541823 | 0.81 | NPC1 (0.71) | MAPTDYRK1ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL16732745 | 0.81 | DYRK1A (0.78) | MAPTDYRK1ASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL2187627 | 0.81 | NPC1 (0.80) | MAPTDYRK1ASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL6295875 | 0.79 | CXCR2 (0.79) | MAPTDYRK1ASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL21568955 | 0.79 | GSK3B (0.76) | MAPTDYRK1ASMN1; SMN2ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017027984-A1 | COMPOUNDS AND METHODS FOR TREATMENT OF CANCER BY INHIBITING ATG4B AND BLOCKING AUTOPHAGY | SIMON FRASER UNIVERSITY (CA) | 2017-02-23 | — | — | WO | disclosed |