SCHEMBL18529463

SCHEMBL18529463

O=CCc1cnc(Oc2ccc(Cl)cc2)cc1C(F)(F)F

nearest known ligand 0.51

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.51
KDM4E B2RXH2 3/20 0.51
MAPK10 P53779 6/20 0.41
L3MBTL1 Q9Y468 3/20 0.40
LIPE Q05469 2/20 0.39
GAA P10253 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
AR P10275 1/20 0.39
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
POLB P06746 1/20 0.38
CYP1A2 P05177 2/20 0.37
CYP2C9 P11712 2/20 0.37
DAGLA Q9Y4D2 1/20 0.36
CYP2C19 P33261 1/20 0.36
ATM Q13315 1/20 0.36
MAPK8 P45983 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20471175 0.88 ALDH1A1 (0.39) ALDH1A1KDM4EMAPK10L3MBTL1POLB
SCHEMBL21459364 0.77 MAPT (0.43) ALDH1A1L3MBTL1GAANPSR1MEN1
SCHEMBL29863514 0.77 MAPT (0.43) ALDH1A1L3MBTL1GAANPSR1MEN1
SCHEMBL21598903 0.75 PIK3R1 (0.37)
SCHEMBL18529455 0.74 KDM4E (0.38) ALDH1A1KDM4EL3MBTL1LIPENPSR1
SCHEMBL18529459 0.74 KDM4E (0.50) ALDH1A1KDM4EMAPK10LIPEGAA
SCHEMBL18529461 0.73 MEN1 (0.55) ALDH1A1KDM4EMAPK10LIPEGAA
SCHEMBL18535700 0.72 POLQ (0.46) KDM4ECYP1A2CYP2C19
SCHEMBL875436 0.72 POLB (0.44) ALDH1A1KDM4EMAPK10L3MBTL1POLB
SCHEMBL19994240 0.69 MEN1 (0.42) ALDH1A1KDM4EL3MBTL1LIPEMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3519389-A1 NOVEL 5-SUBSTITUTED IMIDAZOLYLMETHYL DERIVATIVES Bayer CropScience Aktiengesellschaft (DE) 2019-08-07 EP disclosed
WO-2018145921-A1 COMPOSITION FOR CONTROLLING HARMFUL MICROORGANISMS COMPRISING 1 -(PHENOXY-PYRIDINYL)-2-(1,2,4-TRIAZOL-1 -YL)-ETHANOL DERIVATIVES BAYER AKTIENGESELLSCHAFT (DE) 2018-08-16 WO disclosed
WO-2018145933-A1 TRIAZOLETHIONE DERIVATIVES BAYER AKTIENGESELLSCHAFT (DE) 2018-08-16 WO disclosed
EP-3334718-A1 TRIAZOLE DERIVATIVES, INTERMEDIATES THEREOF AND THEIR USE AS FUNGICIDES Bayer CropScience Aktiengesellschaft (DE) 2018-06-20 EP disclosed
WO-2018060091-A1 NOVEL 5-SUBSTITUTED IMIDAZOLYLMETHYL DERIVATIVES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2018-04-05 WO disclosed
WO-2017029179-A1 TRIAZOLE DERIVATIVES, INTERMEDIATES THEREOF AND THEIR USE AS FUNGICIDES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2017-02-23 WO disclosed