Sugi Predict

Sugi Predict / Compounds / SCHEMBL434786

SCHEMBL434786

SCHEMBL434786

CCOC(=O)COc1ccc(O)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GAA P10253 2/20 0.68
▸ NPSR1 Q6W5P4 1/20 0.68
▸ HPGD P15428 2/20 0.57
▸ KDM4E B2RXH2 2/20 0.55
▸ HSD17B10 Q99714 2/20 0.55
▸ ALDH1A1 P00352 1/20 0.55
▸ TP53 P04637 1/20 0.55
▸ MAPT P10636 1/20 0.55
▸ ALDH2 P05091 1/20 0.54
▸ POLB P06746 1/20 0.54
▸ LTA4H P09960 1/20 0.53
▸ TBXAS1 P24557 1/20 0.52
▸ SMN1; SMN2 Q16637 1/20 0.52
▸ CA12 O43570 1/20 0.52
▸ CA1 P00915 1/20 0.52
▸ CA2 P00918 1/20 0.52
▸ ESR1 P03372 1/20 0.52
▸ CA7 P43166 1/20 0.52
▸ CA9 Q16790 1/20 0.52
▸ ESR2 Q92731 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1853201 0.95 GAA (0.62) GAANPSR1HPGDKDM4EHSD17B10
SCHEMBL1550341 0.92 GAA (0.59) GAANPSR1HPGDKDM4EHSD17B10
SCHEMBL29226837 0.89 GAA (0.56) GAANPSR1HPGDKDM4EHSD17B10
SCHEMBL11815554 0.89 GAA (0.72) GAANPSR1HPGDKDM4EHSD17B10
SCHEMBL1107148 0.87 GAA (0.70) GAANPSR1HPGDKDM4EHSD17B10
SCHEMBL11550281 0.87 GAA (0.70) GAANPSR1HPGDKDM4EHSD17B10
SCHEMBL9267668 0.87 GAA (0.70) GAANPSR1HPGDKDM4EHSD17B10
SCHEMBL7692043 0.85 GAA (0.68) GAANPSR1HPGDKDM4EHSD17B10
SCHEMBL10867147 0.85 GAA (0.68) GAANPSR1HPGDKDM4EHSD17B10
SCHEMBL14402167 0.85 GAA (0.68) GAANPSR1HPGDKDM4EHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 118 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108239029-B Preparation and medical application of tetrahydroisoquinoline compounds and salts thereof 中国医学科学院药物研究所 2021-04-13 — — CN disclosed
EP-2595952-B1 AGONISTS OF GPR40 CONNEXIOS LIFE SCIENCES PVT LTD (IN) 2020-11-18 — — EP disclosed
US-9278915-B2 Agonists of GPR40 CONNEXIOS LIFE SCIENCES PVT LTD (IN) 2016-03-08 — — US disclosed
US-9278915-B2 Agonists of GPR40 CONNEXIOS LIFE SCIENCES PVT LTD (IN) 2016-03-08 — — US disclosed
CN-103228622-B The agonist of GPR40 CONNEXIOS LIFE SCIENCES Pvt.,Ltd. (IN) 2016-01-20 — — CN disclosed
EP-2582674-B1 GPR120 RECEPTOR AGONISTS AND USES THEREOF CYMABAY THERAPEUTICS INC (US) 2014-10-01 — — EP disclosed
EP-2582674-B1 GPR120 RECEPTOR AGONISTS AND USES THEREOF CYMABAY THERAPEUTICS INC (US) 2014-10-01 — — EP disclosed
CN-103980235-A GPR120 receptor agonists and uses thereof CYMABAY THERAPEUTICS INC 2014-08-13 — — CN disclosed
CN-102307860-B GPR120 receptor agonists and uses thereof METABOLEX INC 2014-07-02 — — CN disclosed
US-20140121246-A1 GPR120 RECEPTOR AGONISTS AND USES THEREOF METABOLEX, INC. (US) 2014-05-01 — — US disclosed
EP-0029319-B1 QUINOLINYLOXY(AMINO)PHENOXYALKANE CARBOXYLIC ACID DERIVATIVES, PROCESS FOR THEIR SYNTHESIS, HERBICIDAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS HERBICIDES ICI AUSTRALIA LIMITED (AU) 1986-01-15 — — EP disclosed
EP-0048539-B1 ISOQUINOLYLOXY(AMINO)PHENOXYALKANE CARBOXYLIC ACID DERIVATIVES, PROCESS FOR THEIR SYNTHESIS, HERBICIDAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS HERBICIDES ICI AUSTRALIA LIMITED (AU) 1985-08-28 — — EP disclosed
EP-0024932-B1 1,2,4-BENZOTRIAZINYLOXYPHENOXYALKANE CARBOXYLIC-ACID DERIVATIVES, PROCESSES FOR THEIR PREPARATION, THEIR USE AS HERBICIDES, AND THEIR PREPARATION ICI AUSTRALIA LIMITED (AU) 1984-08-01 — — EP disclosed
US-4444584-A Ethyl 2[4-(7-chloroquinolin-3-yloxy)phenoxy]propionate, the N-oxide, and herbicidal compositions and methods employing them ICI AUSTRALIA LIMITED (AU) 1984-04-24 — — US disclosed
EP-0098751-A2 Quinolinyloxy(amino)phenols and alkoxyphenyloxy(amino)quinolines ICI AUSTRALIA LIMITED (AU) 1984-01-18 — — EP disclosed
US-4409017-A Herbicidal isoquinolinoxy- or isoquinolinamino-phenoxy alkane carboxylic acid derivatives ICI AUSTRALIA LIMITED (AU) 1983-10-11 — — US disclosed
EP-0048539-A1 Isoquinolyloxy(amino)phenoxyalkane carboxylic acid derivatives, process for their synthesis, herbicidal compositions containing them and their use as herbicides ICI AUSTRALIA LIMITED (AU) 1982-03-31 — — EP disclosed
US-4309211-A Herbicidal 1,2,4-benzotriazines ICI AUSTRALIA LIMITED (AU) 1982-01-05 — — US disclosed
EP-0029319-A2 Quinolinyloxy(amino)phenoxyalkane carboxylic acid derivatives, process for their synthesis, herbicidal compositions containing them and their use as herbicides ICI AUSTRALIA LIMITED (AU) 1981-05-27 — — EP disclosed
EP-0024932-A2 1,2,4-Benzotriazinyloxyphenoxyalkane carboxylic-acid derivatives, processes for their preparation, their use as herbicides, and their preparation ICI AUSTRALIA LIMITED (AU) 1981-03-11 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140121246-A1 GPR120 RECEPTOR AGONISTS AND USES THEREOF GPR119, GPR52, GCGR GAA 648/4885NPSR1 239/4885HPGD 2073/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.