Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.64 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.55 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.51 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.50 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.50 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.50 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1851267 | 0.93 | HDAC8 (0.58) | HDAC8HDAC2HDAC1SIRT2SPHK1 | |
| SCHEMBL4669852 | 0.89 | HDAC8 (0.58) | HDAC8HDAC2HDAC1SIRT2SPHK1 | |
| SCHEMBL1857841 | 0.89 | HDAC8 (0.56) | HDAC8HDAC2HDAC1SIRT2SPHK1 | |
| SCHEMBL1854710 | 0.88 | HDAC1 (0.55) | HDAC8HDAC2HDAC1SIRT2SPHK1 | |
| SCHEMBL6725294 | 0.82 | S1PR1 (0.62) | HDAC8HDAC2HDAC1SIRT2SPHK1 | |
| SCHEMBL6424097 | 0.82 | SPHK1 (0.47) | HDAC8HDAC2HDAC1SPHK1S1PR1 | |
| Hydrochloric Acid SCHEMBL1856614 | 0.81 | S1PR1 (0.61) | HDAC8HDAC2HDAC1SIRT2SPHK1 | |
| SCHEMBL6022624 | 0.81 | SPHK1 (0.46) | HDAC8HDAC2HDAC1SPHK1S1PR2 | |
| SCHEMBL5047433 | 0.81 | SIRT2 (0.58) | HDAC8HDAC2HDAC1SIRT2SPHK1 | |
| Trifluoroacetic Acid SCHEMBL26690855 | 0.80 | SPHK1 (0.59) | HDAC8HDAC2HDAC1SPHK1S1PR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470102-B1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | MERCK SERONO SA (CH) | 2011-05-25 | — | — | EP | disclosed |
| US-20050124656-A1 | Substituted methylene amide derivatives as modulators of protein tyrosine phosphatases(ptps) | APPLIED RESEARCH SYSTEMS ARS (NL) | 2005-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124656-A1 | Substituted methylene amide derivatives as modulators of protein tyrosine phosphatases(ptps) | PTPRS, PTPA, PTPMT1 | HDAC8 2841/4885HDAC2 3297/4885HDAC1 2136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.