Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 2/20 | 0.62 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.62 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.62 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.61 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.59 |
| ▸ | SPHK1 | Q9NYA1 | 5/20 | 0.51 |
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1856614 | 0.99 | S1PR1 (0.61) | S1PR1S1PR3S1PR2LPAR2HDAC1 | |
| SCHEMBL15705335 | 0.85 | S1PR2 (0.78) | S1PR1S1PR3S1PR2LPAR2HDAC1 | |
| SCHEMBL5047433 | 0.85 | SIRT2 (0.58) | S1PR1S1PR3S1PR2LPAR2HDAC1 | |
| SCHEMBL1855651 | 0.82 | HDAC1 (0.43) | S1PR1S1PR3S1PR2LPAR2HDAC1 | |
| SCHEMBL1853070 | 0.82 | HDAC1 (0.43) | S1PR1S1PR3S1PR2LPAR2HDAC1 | |
| SCHEMBL1853227 | 0.82 | HDAC8 (0.64) | S1PR1S1PR3S1PR2LPAR2HDAC1 | |
| SCHEMBL1851267 | 0.82 | HDAC8 (0.58) | S1PR1S1PR3S1PR2LPAR2HDAC1 | |
| SCHEMBL1855183 | 0.80 | SPHK1 (0.51) | S1PR1S1PR3S1PR2LPAR2HDAC1 | |
| SCHEMBL6725380 | 0.80 | SPHK1 (0.51) | S1PR1S1PR3S1PR2LPAR2HDAC1 | |
| SCHEMBL5047430 | 0.80 | HDAC8 (0.53) | S1PR1S1PR3S1PR2LPAR2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470102-A1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | Applied Research Systems ARS Holding N.V. (AN) | 2004-10-27 | — | — | EP | disclosed |
| WO-2003064376-A1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2003-08-07 | — | — | WO | disclosed |