Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.56 |
| ▸ | SPHK1 | Q9NYA1 | 4/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.49 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.49 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.48 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6725294 | 0.85 | S1PR1 (0.62) | SIRT2HDAC1HDAC2HDAC8SPHK1 | |
| Hydrochloric Acid SCHEMBL1856614 | 0.84 | S1PR1 (0.61) | SIRT2HDAC1HDAC2HDAC8SPHK1 | |
| SCHEMBL4969074 | 0.81 | SPHK1 (0.45) | SPHK1S1PR1PPARANPC1RAB9A | |
| SCHEMBL1853227 | 0.81 | HDAC8 (0.64) | SIRT2HDAC1HDAC2HDAC8SPHK1 | |
| SCHEMBL4669852 | 0.78 | HDAC8 (0.58) | SIRT2HDAC1HDAC2HDAC8SPHK1 | |
| SCHEMBL5047430 | 0.78 | HDAC8 (0.53) | SIRT2HDAC1HDAC2HDAC8SPHK1 | |
| SCHEMBL1851267 | 0.78 | HDAC8 (0.58) | SIRT2HDAC1HDAC2HDAC8SPHK1 | |
| SCHEMBL3264894 | 0.78 | SPHK1 (0.67) | SIRT2SPHK1S1PR1S1PR3S1PR2 | |
| SCHEMBL1854708 | 0.77 | HDAC8 (0.56) | SIRT2HDAC1HDAC2HDAC8SPHK1 | |
| SCHEMBL1857841 | 0.76 | HDAC8 (0.56) | SIRT2HDAC1HDAC2HDAC8SPHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |