Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | JAK1 | P23458 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 18/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18534753 | 0.89 | JAK2 (0.39) | JAK2JAK1JAK3IRAK4 | |
| SCHEMBL18534778 | 0.88 | JAK2 (0.39) | JAK2JAK1JAK3 | |
| SCHEMBL18534427 | 0.84 | JAK3 (0.34) | JAK2JAK1JAK3IRAK4 | |
| SCHEMBL18535179 | 0.80 | LMNA (0.36) | IRAK4 | |
| SCHEMBL18534483 | 0.77 | JAK2 (0.35) | JAK2JAK1JAK3IRAK4 | |
| SCHEMBL1370294 | 0.77 | JAK2 (0.39) | JAK2JAK1JAK3IRAK4 | |
| SCHEMBL18534856 | 0.77 | CNR1 (0.31) | — | |
| SCHEMBL18534410 | 0.76 | CSNK1D (0.34) | IRAK4 | |
| SCHEMBL12146322 | 0.75 | JAK3 (0.71) | JAK2JAK1JAK3 | |
| SCHEMBL18534438 | 0.66 | ALOX5AP (0.31) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2017-02-22 | — | — | EP | disclosed |