Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 17/20 | 0.47 |
| ▸ | JAK2 | O60674 | 13/20 | 0.44 |
| ▸ | JAK1 | P23458 | 13/20 | 0.44 |
| ▸ | SYK | P43405 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18534664 | 1.00 | JAK3 (0.47) | JAK3JAK2JAK1SYKCYP2C9 | |
| SCHEMBL18534629 | 0.90 | JAK3 (0.46) | JAK3JAK2JAK1SYKCYP2C9 | |
| SCHEMBL18534622 | 0.86 | JAK3 (0.46) | JAK3JAK2JAK1SYKCYP2C9 | |
| SCHEMBL18534999 | 0.86 | JAK3 (0.46) | JAK3JAK2JAK1SYKCYP2C9 | |
| SCHEMBL18534795 | 0.86 | JAK3 (0.46) | JAK3JAK2JAK1SYKCYP2C9 | |
| SCHEMBL18534625 | 0.86 | JAK3 (0.45) | JAK3JAK2JAK1SYKCYP2C9 | |
| SCHEMBL18534813 | 0.86 | JAK3 (0.45) | JAK3JAK2JAK1SYKCYP2C9 | |
| SCHEMBL18534839 | 0.84 | JAK3 (0.50) | JAK3JAK2JAK1SYK | |
| SCHEMBL18534642 | 0.84 | JAK3 (0.50) | JAK3JAK2JAK1SYK | |
| SCHEMBL18534530 | 0.83 | JAK3 (0.46) | JAK3JAK2JAK1SYKCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2017-02-22 | — | — | EP | disclosed |