Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 2/20 | 0.31 |
| ▸ | CNR2 | P34972 | 2/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18534427 | 0.84 | JAK3 (0.34) | CNR1CNR2PDE2A | |
| SCHEMBL18534680 | 0.83 | PDE2A (0.40) | CNR1CNR2PDE2AADORA2A | |
| SCHEMBL18534753 | 0.81 | JAK2 (0.39) | CNR2 | |
| SCHEMBL18534778 | 0.80 | JAK2 (0.39) | — | |
| SCHEMBL18534776 | 0.78 | CNR2 (0.32) | CNR1CNR2 | |
| SCHEMBL14751064 | 0.77 | DGAT1 (0.34) | ADORA2AADORA1 | |
| SCHEMBL14751056 | 0.77 | DGAT1 (0.34) | ADORA2AADORA1 | |
| SCHEMBL14751203 | 0.77 | DGAT1 (0.34) | ADORA2AADORA1 | |
| SCHEMBL18534790 | 0.77 | MEN1 (0.31) | — | |
| SCHEMBL18534669 | 0.77 | JAK2 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2017-02-22 | — | — | EP | disclosed |