Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 3/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.31 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 2/20 | 0.31 |
| ▸ | JAK3 | P52333 | 2/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | TEK | Q02763 | 1/20 | 0.30 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL186120 | 0.92 | JAK1 (0.34) | FAAHTRPV1MAP4K1JAK1JAK3 | |
| SCHEMBL2806523 | 0.91 | BDKRB1 (0.33) | MAP4K1JAK1JAK3JAK2PTGS2 | |
| SCHEMBL185136 | 0.87 | OPRL1 (0.32) | FAAHTRPV1 | |
| SCHEMBL185040 | 0.87 | MAPK3 (0.34) | FAAHTRPV1KDRTEK | |
| SCHEMBL186646 | 0.84 | L3MBTL1 (0.35) | FAAHTRPV1LCK | |
| SCHEMBL2809213 | 0.82 | JAK1 (0.34) | MAP4K1JAK1JAK3JAK2PTGS2 | |
| SCHEMBL185223 | 0.81 | FAAH (0.35) | FAAHTRPV1 | |
| Hydrochloric Acid SCHEMBL185917 | 0.80 | FAAH (0.32) | FAAHTRPV1PTGS2 | |
| SCHEMBL14856612 | 0.79 | MAPK10 (0.33) | FAAHTRPV1KDRTEK | |
| SCHEMBL185613 | 0.79 | SMO (0.33) | FAAHTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |