Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.41 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | SMPD3 | Q9NY59 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15879837 | 0.79 | DYRK1A (0.40) | DYRK1APDE10AMAP3K12SMPD3JAK3 | |
| SCHEMBL14701496 | 0.79 | DYRK1A (0.40) | DYRK1APDE10AMAP3K12SMPD3JAK3 | |
| SCHEMBL15891142 | 0.79 | DYRK1A (0.40) | DYRK1APDE10AMAP3K12SMPD3JAK3 | |
| SCHEMBL18150306 | 0.78 | ROCK2 (0.43) | NR1H2NR1H3 | |
| SCHEMBL18150307 | 0.78 | ROCK2 (0.43) | NR1H2NR1H3 | |
| SCHEMBL15515804 | 0.78 | ELANE (0.40) | NR1H2NR1H3SMN1; SMN2 | |
| SCHEMBL15509236 | 0.78 | ELANE (0.40) | NR1H2NR1H3SMN1; SMN2 | |
| SCHEMBL15508946 | 0.78 | ELANE (0.40) | NR1H2NR1H3SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL18149792 | 0.77 | ROCK2 (0.43) | NR1H2NR1H3 | |
| Hydrochloric Acid SCHEMBL18149790 | 0.77 | ROCK2 (0.43) | NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2909212-B1 | SUBSTITUTED 1,4-DIHYDROPYRAZOLO[4,3-B]INDOLES | TAKEDA PHARMACEUTICALS CO (JP) | 2017-02-22 | — | — | EP | disclosed |