Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.38 |
| ▸ | SMPD3 | Q9NY59 | 2/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15891142 | 1.00 | DYRK1A (0.40) | DYRK1AMAP3K12JAK3KDM4EALDH1A1 | |
| SCHEMBL15879837 | 1.00 | DYRK1A (0.40) | DYRK1AMAP3K12JAK3KDM4EALDH1A1 | |
| SCHEMBL17210377 | 0.95 | ALDH1A1 (0.44) | DYRK1AMAP3K12JAK3KDM4EALDH1A1 | |
| SCHEMBL17201983 | 0.95 | ALDH1A1 (0.44) | DYRK1AMAP3K12JAK3KDM4EALDH1A1 | |
| SCHEMBL22793078 | 0.84 | DYRK1A (0.44) | DYRK1AMAP3K12JAK3ALDH1A1PDE10A | |
| SCHEMBL19396079 | 0.82 | DYRK1A (0.40) | DYRK1AMAP3K12JAK3ALDH1A1MEN1 | |
| SCHEMBL8272981 | 0.79 | DYRK1A (0.49) | DYRK1AMAP3K12JAK3ALDH1A1LRRK2 | |
| SCHEMBL5774649 | 0.79 | DYRK1A (0.49) | DYRK1AMAP3K12JAK3ALDH1A1LRRK2 | |
| SCHEMBL26691316 | 0.79 | DYRK1A (0.49) | DYRK1AMAP3K12JAK3ALDH1A1LRRK2 | |
| SCHEMBL18536638 | 0.79 | DYRK1A (0.42) | DYRK1AMAP3K12JAK3ALDH1A1PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3134410-B1 | INHIBITING THE TRANSIENT RECEPTOR POTENTIAL A1 ION CHANNEL | LILLY CO ELI (US) | 2021-03-10 | — | — | EP | disclosed |
| EP-3134410-B1 | INHIBITING THE TRANSIENT RECEPTOR POTENTIAL A1 ION CHANNEL | LILLY CO ELI (US) | 2021-03-10 | — | — | EP | disclosed |
| US-10428072-B2 | Inhibiting the transient receptor potential A1 ion channel | ELI LILLY AND COMPANY (US) | 2019-10-01 | — | — | US | disclosed |
| US-20170050966-A1 | INHIBITING THE TRANSIENT RECEPTOR POTENTIAL A1 ION CHANNEL | MERCK & CO., INC. | 2017-02-23 | — | — | US | disclosed |
| US-20170050966-A1 | INHIBITING THE TRANSIENT RECEPTOR POTENTIAL A1 ION CHANNEL | MERCK & CO., INC. | 2017-02-23 | — | — | US | disclosed |
| US-20170050966-A1 | INHIBITING THE TRANSIENT RECEPTOR POTENTIAL A1 ION CHANNEL | MERCK & CO., INC. | 2017-02-23 | — | — | US | disclosed |
| US-9394308-B2 | Inhibiting the transient receptor potential A1 ion channel | MERCK SHARP & DOHME CORP. (US) | 2016-07-19 | — | — | US | disclosed |
| US-9394308-B2 | Inhibiting the transient receptor potential A1 ion channel | MERCK SHARP & DOHME CORP. (US) | 2016-07-19 | — | — | US | disclosed |
| US-9394308-B2 | Inhibiting the transient receptor potential A1 ion channel | MERCK SHARP & DOHME CORP. (US) | 2016-07-19 | — | — | US | disclosed |
| EP-2742048-B1 | INHIBITING TRANSIENT RECEPTOR POTENTIAL ION CHANNEL TRPA1 | HYDRA BIOSCIENCES INC (US) | 2016-04-27 | — | — | EP | disclosed |
| US-20140206650-A1 | INHIBITING THE TRANSIENT RECEPTOR POTENTIAL A1 ION CHANNEL | MERCK SHARP & DOHME LLC | 2014-07-24 | — | — | US | disclosed |
| US-20140206650-A1 | INHIBITING THE TRANSIENT RECEPTOR POTENTIAL A1 ION CHANNEL | MERCK SHARP & DOHME LLC | 2014-07-24 | — | — | US | disclosed |
| US-20140206650-A1 | INHIBITING THE TRANSIENT RECEPTOR POTENTIAL A1 ION CHANNEL | MERCK SHARP & DOHME LLC | 2014-07-24 | — | — | US | disclosed |
| US-20140158116-A1 | INHIBITING TRPA1 FOR THE TREATMENT OF ASTHMA | CUBIST PHARMACEUTICALS, INC. (US) | 2014-06-12 | — | — | US | disclosed |
| US-20140163048-A1 | COMPOSITIONS WITH INCREASED STABILITY FOR INHIBITING TRANSIENT RECEPTOR POTENTIAL ION CHANNEL TRPA1 | CUBIST PHARMACEUTICALS, INC. (US) | 2014-06-12 | — | — | US | disclosed |
| US-20140163048-A1 | COMPOSITIONS WITH INCREASED STABILITY FOR INHIBITING TRANSIENT RECEPTOR POTENTIAL ION CHANNEL TRPA1 | CUBIST PHARMACEUTICALS, INC. (US) | 2014-06-12 | — | — | US | disclosed |
| US-20140158116-A1 | INHIBITING TRPA1 FOR THE TREATMENT OF ASTHMA | CUBIST PHARMACEUTICALS, INC. (US) | 2014-06-12 | — | — | US | disclosed |
| US-20130274273-A1 | Inhibiting Transient Receptor Potential Ion Channel TRPA1 | CUBIST PHARMACEUTICALS, INC. (US) | 2013-10-17 | — | — | US | disclosed |
| US-20130274273-A1 | Inhibiting Transient Receptor Potential Ion Channel TRPA1 | CUBIST PHARMACEUTICALS, INC. (US) | 2013-10-17 | — | — | US | disclosed |
| WO-2013023102-A1 | INHIBITING TRANSIENT RECEPTOR POTENTIAL ION CHANNEL TRPA1 | HYDRA BIOSCIENCES, INC. (US) | 2013-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10428072-B2 | Inhibiting the transient receptor potential A1 ion channel | TRPA1, TRPV1, TRPV2 | DYRK1A 2860/4885MAP3K12 1885/4885JAK3 4469/4885 |
| US-20130274273-A1 | Inhibiting Transient Receptor Potential Ion Channel TRPA1 | TRPA1, TRPV1, TRPV2 | DYRK1A 4358/4885MAP3K12 2437/4885JAK3 4779/4885 |
| US-20170050966-A1 | INHIBITING THE TRANSIENT RECEPTOR POTENTIAL A1 ION CHANNEL | TRPA1, TRPV1, TRPV2 | DYRK1A 2860/4885MAP3K12 1885/4885JAK3 4469/4885 |
| US-20140206650-A1 | INHIBITING THE TRANSIENT RECEPTOR POTENTIAL A1 ION CHANNEL | TRPA1, TRPV1, TRPV2 | DYRK1A 4352/4885MAP3K12 2558/4885JAK3 4817/4885 |
| US-20140158116-A1 | INHIBITING TRPA1 FOR THE TREATMENT OF ASTHMA | TRPA1, TRPV1, TRPV2 | DYRK1A 4607/4885MAP3K12 2299/4885JAK3 4521/4885 |
| US-20140163048-A1 | COMPOSITIONS WITH INCREASED STABILITY FOR INHIBITING TRANSIENT RECEPTOR POTENTIAL ION CHANNEL TRPA1 | TRPA1, TRPV1, TRPV2 | DYRK1A 4211/4885MAP3K12 2849/4885JAK3 4836/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.