Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | GRM5 | P41594 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | CXCR6 | O00574 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9970054 | 0.83 | SMN1; SMN2 (0.54) | SMN1; SMN2RAB9ANPC1PKMGRM5 | |
| Trifluoroacetic Acid SCHEMBL2068008 | 0.78 | NPC1 (0.49) | SMN1; SMN2RAB9ANPC1PKMGRM5 | |
| SCHEMBL13490741 | 0.77 | MEN1 (0.54) | SMN1; SMN2RAB9ANPC1PKMGRM5 | |
| SCHEMBL13490372 | 0.77 | MEN1 (0.54) | SMN1; SMN2RAB9ANPC1PKMGRM5 | |
| SCHEMBL13490618 | 0.77 | MEN1 (0.54) | SMN1; SMN2RAB9ANPC1PKMGRM5 | |
| SCHEMBL14192268 | 0.77 | MEN1 (0.54) | SMN1; SMN2RAB9ANPC1PKMGRM5 | |
| Hydrochloric Acid SCHEMBL3218463 | 0.76 | CXCR6 (0.53) | SMN1; SMN2RAB9ANPC1PKMGRM5 | |
| Hydrochloric Acid SCHEMBL3213396 | 0.76 | CXCR6 (0.53) | SMN1; SMN2RAB9ANPC1PKMGRM5 | |
| SCHEMBL2468483 | 0.74 | NPC1 (0.71) | SMN1; SMN2RAB9ANPC1PKMGRM5 | |
| SCHEMBL13490400 | 0.74 | HTR2B (0.56) | SMN1; SMN2RAB9ANPC1PKMGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170860-B9 | BENZIMIDAZOLE DERIVATIVES | PFIZER (US) | 2017-02-22 | — | — | EP | disclosed |