SCHEMBL18537183

SCHEMBL18537183

CC1COC(c2ccccc2)(c2ccc(N(C)C)cc2)OC1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRA1A P35348 2/20 0.39
GRIN1 Q05586 1/20 0.38
GRIN2A Q12879 1/20 0.38
ALDH1A1 P00352 3/20 0.37
HSD17B10 Q99714 3/20 0.37
TSHR P16473 2/20 0.37
TDP1 Q9NUW8 2/20 0.37
MAPK1 P28482 1/20 0.37
RELA Q04206 1/20 0.37
OPRL1 P41146 2/20 0.37
CHRNB2 P17787 1/20 0.36
SLC6A2 P23975 1/20 0.36
CHRNB4 P30926 1/20 0.36
CHRNA3 P32297 1/20 0.36
CHRNA4 P43681 1/20 0.36
SLC6A3 Q01959 1/20 0.36
ALOX15 P16050 1/20 0.35
OPRM1 P35372 1/20 0.35
OPRK1 P41145 1/20 0.35
ADRA1B P35368 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14039677 0.86 GRIN1 (0.45) ADRA1AGRIN1GRIN2AHSD17B10CHRNB2
SCHEMBL18287990 0.83 ALDH1A1 (0.41) ALDH1A1HSD17B10TSHRTDP1MAPK1
SCHEMBL18287974 0.80 ALDH1A1 (0.39) ALDH1A1HSD17B10TSHRTDP1MAPK1
SCHEMBL18287977 0.80 ALDH1A1 (0.39) ALDH1A1HSD17B10TSHRTDP1MAPK1
SCHEMBL14039895 0.80 NPY1R (0.40) ADRA1AGRIN1GRIN2ACHRNB2SLC6A2
SCHEMBL18287916 0.79 ALDH1A1 (0.38) ALDH1A1HSD17B10TSHRTDP1MAPK1
SCHEMBL18287965 0.75 ALDH1A1 (0.48) ALDH1A1HSD17B10TSHRTDP1MAPK1
SCHEMBL18287969 0.72 ALDH1A1 (0.44) ALDH1A1HSD17B10TSHRTDP1MAPK1
SCHEMBL14039981 0.72 SLC6A3 (0.42) CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4
SCHEMBL14039761 0.72 SLC6A3 (0.42) GRIN1GRIN2AALDH1A1HSD17B10TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3133445-A1 CHEMICALLY AMPLIFIED RESIST MATERIAL OSAKA UNIVERSITY (JP) 2017-02-22 EP disclosed