Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 7/20 | 0.40 |
| ▸ | STK17B | O94768 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3209928 | 0.88 | NPC1 (0.45) | STK17BNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL1854107 | 0.83 | ALDH1A1 (0.49) | ERN1NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL1855273 | 0.82 | RAB9A (0.47) | ERN1NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3221809 | 0.79 | NPC1 (0.43) | STK17BNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL1852383 | 0.75 | RAB9A (0.57) | STK17BNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL1848516 | 0.72 | NPC1 (0.48) | STK17BNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL1850138 | 0.69 | SRD5A2 (0.48) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL3215728 | 0.69 | NPC1 (0.45) | STK17BNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3204959 | 0.69 | ALDH1A1 (0.60) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL91201 | 0.68 | ERN1 (0.61) | ERN1NPC1RAB9ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323978-A1 | AMIDE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010018874-A1 | AMIDE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-02-18 | — | — | WO | disclosed |