Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 7/20 | 0.68 |
| ▸ | CDK8 | P49336 | 1/20 | 0.49 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.45 |
| ▸ | HPGD | P15428 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 4/20 | 0.45 |
| ▸ | ATM | Q13315 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | GLA | P06280 | 2/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | CHUK | O15111 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | PRKACG | P22612 | 1/20 | 0.43 |
| ▸ | PRKACB | P22694 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18537594 | 0.81 | CDK8 (0.67) | CDK8CDK19L3MBTL1POLBKDM4E | |
| SCHEMBL19000082 | 0.81 | IKBKB (0.64) | IKBKBCDK8CDK19L3MBTL1POLB | |
| SCHEMBL3173443 | 0.81 | IKBKB (1.00) | IKBKBCDK8CDK19L3MBTL1POLB | |
| SCHEMBL18537675 | 0.78 | KDM4E (0.61) | IKBKBPOLBKDM4EALDH1A1HPGD | |
| SCHEMBL18537728 | 0.72 | IKBKB (0.65) | IKBKBCDK8CDK19L3MBTL1POLB | |
| SCHEMBL18537629 | 0.71 | ALDH1A1 (0.64) | IKBKBCDK8CDK19KDM4EALDH1A1 | |
| SCHEMBL19000276 | 0.71 | ALDH1A1 (0.52) | IKBKBL3MBTL1KDM4EALDH1A1HPGD | |
| SCHEMBL21704232 | 0.71 | KDM4E (0.40) | IKBKBCDK8CDK19POLBKDM4E | |
| SCHEMBL18537604 | 0.70 | IKBKB (0.47) | IKBKBCDK8CDK19L3MBTL1POLB | |
| SCHEMBL6384917 | 0.70 | IKBKB (0.81) | IKBKBCDK8CDK19L3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2400845-B1 | THIENOPYRIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DENGUE VIRUS INFECTIONS | SIGA TECH INC (US) | 2017-02-22 | — | — | EP | disclosed |