Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 2/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.34 |
| ▸ | FAAH | O00519 | 4/20 | 0.34 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 3/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2805264 | 0.90 | BDKRB1 (0.40) | LCKACVRL1AURKAJAK2AURKB | |
| SCHEMBL3728256 | 0.79 | P2RY1 (0.37) | TRPV1FAAH | |
| SCHEMBL185223 | 0.76 | FAAH (0.35) | TRPV1FAAHAURKAMAPK9MAPK10 | |
| SCHEMBL3725823 | 0.76 | ABL1 (0.38) | TRPV1FAAHMAPK14 | |
| SCHEMBL186651 | 0.74 | CNR2 (0.39) | TRPV1MAPK10KDM4EGRM5ALDH1A1 | |
| SCHEMBL185613 | 0.73 | SMO (0.33) | TRPV1FAAHMAPK10GRM5 | |
| SCHEMBL14856612 | 0.73 | MAPK10 (0.33) | TRPV1FAAHMAPK10GRM5ALDH1A1 | |
| SCHEMBL185374 | 0.73 | MEN1 (0.47) | TRPV1FAAHAURKABDKRB1 | |
| SCHEMBL185885 | 0.71 | FAAH (0.35) | TRPV1FAAHCYP2C9KDM4EGRM5 | |
| SCHEMBL186120 | 0.71 | JAK1 (0.34) | LCKTRPV1FAAHJAK2MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |