Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAMBP | O95630 | 6/20 | 0.74 |
| ▸ | PSMD14 | O00487 | 5/20 | 0.74 |
| ▸ | COPS5 | Q92905 | 4/20 | 0.58 |
| ▸ | MMP13 | P45452 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18539646 | 0.88 | STAMBP (0.73) | STAMBPPSMD14COPS5MMP13LMNA | |
| SCHEMBL13978048 | 0.88 | PSMD14 (0.72) | STAMBPPSMD14COPS5L3MBTL1 | |
| SCHEMBL18526841 | 0.85 | STAMBP (1.00) | STAMBPPSMD14COPS5 | |
| SCHEMBL18539647 | 0.83 | STAMBP (0.74) | STAMBPPSMD14COPS5L3MBTL1 | |
| SCHEMBL18539648 | 0.81 | STAMBP (0.77) | STAMBPPSMD14COPS5 | |
| SCHEMBL18539644 | 0.81 | PSMD14 (0.74) | STAMBPPSMD14COPS5L3MBTL1LMNA | |
| SCHEMBL18539650 | 0.80 | STAMBP (0.76) | STAMBPPSMD14COPS5ALDH1A1NPC1 | |
| SCHEMBL18539640 | 0.79 | PSMD14 (0.75) | STAMBPPSMD14COPS5 | |
| SCHEMBL18539649 | 0.78 | PSMD14 (0.77) | PSMD14COPS5MMP13LMNAALDH1A1 | |
| SCHEMBL18539638 | 0.77 | PSMD14 (0.74) | STAMBPPSMD14COPS5ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10005735-B2 | Inhibitors of RPN11 | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2018-06-26 | — | — | US | disclosed |
| US-10005735-B2 | Inhibitors of RPN11 | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2018-06-26 | — | — | US | disclosed |
| WO-2017031255-A1 | INHIBITORS OF RPN11 | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2017-02-23 | — | — | WO | disclosed |
| US-20170050931-A1 | INHIBITORS OF RPN11 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2017-02-23 | — | — | US | disclosed |
| US-20170050931-A1 | INHIBITORS OF RPN11 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2017-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170050931-A1 | INHIBITORS OF RPN11 | POLR2A, RPP30, RPIA | STAMBP 3835/4885PSMD14 418/4885COPS5 700/4885 |
| US-10005735-B2 | Inhibitors of RPN11 | POLR2A, RPP30, RPIA | STAMBP 3835/4885PSMD14 418/4885COPS5 700/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.