Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | PSMD14 | O00487 | 10/20 | 0.52 |
| ▸ | STAMBP | O95630 | 8/20 | 0.52 |
| ▸ | COPS5 | Q92905 | 7/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | GRK2 | P25098 | 1/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18539662 | 0.86 | STAMBP (0.58) | MAPK1LMNAMAPTPSMD14STAMBP | |
| SCHEMBL18541889 | 0.84 | STAMBP (0.56) | MAPK1LMNAMAPTPSMD14STAMBP | |
| SCHEMBL29563919 | 0.81 | PSMD14 (0.76) | PSMD14STAMBPCOPS5 | |
| SCHEMBL18539642 | 0.81 | PSMD14 (0.76) | PSMD14STAMBPCOPS5 | |
| SCHEMBL18539654 | 0.80 | STAMBP (0.51) | MAPK1MAPTPSMD14STAMBPCOPS5 | |
| SCHEMBL18539643 | 0.78 | PSMD14 (0.76) | LMNAMAPTPSMD14STAMBPCOPS5 | |
| SCHEMBL18539653 | 0.77 | PSMD14 (0.52) | MAPK1MAPTPSMD14STAMBPCOPS5 | |
| SCHEMBL21593797 | 0.77 | MAPT (0.55) | MAPK1LMNAMAPTPSMD14STAMBP | |
| SCHEMBL18539655 | 0.77 | PSMD14 (0.49) | LMNAPSMD14STAMBPCOPS5 | |
| SCHEMBL13978048 | 0.77 | PSMD14 (0.72) | PSMD14STAMBPCOPS5NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10005735-B2 | Inhibitors of RPN11 | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2018-06-26 | — | — | US | disclosed |
| US-10005735-B2 | Inhibitors of RPN11 | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2018-06-26 | — | — | US | disclosed |
| US-20170050931-A1 | INHIBITORS OF RPN11 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2017-02-23 | — | — | US | disclosed |
| US-20170050931-A1 | INHIBITORS OF RPN11 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2017-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170050931-A1 | INHIBITORS OF RPN11 | POLR2A, RPP30, RPIA | MAPK1 2112/4885LMNA 1673/4885MAPT 1647/4885 |
| US-10005735-B2 | Inhibitors of RPN11 | POLR2A, RPP30, RPIA | MAPK1 2112/4885LMNA 1673/4885MAPT 1647/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.