Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | CTSH | P09668 | 1/20 | 0.31 |
| ▸ | METAP2 | P50579 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18550512 | 0.83 | KDM4E (0.54) | KDM4EHPGDUSP2HSD17B10ALDH1A1 | |
| SCHEMBL19762005 | 0.79 | ALDH1A1 (0.56) | KDM4EHPGDUSP2HSD17B10ALDH1A1 | |
| SCHEMBL17937016 | 0.73 | KDM4E (0.43) | KDM4EHPGDUSP2HSD17B10ALDH1A1 | |
| SCHEMBL11403516 | 0.73 | KDM4E (0.62) | KDM4EHPGDUSP2HSD17B10ALDH1A1 | |
| SCHEMBL20061883 | 0.72 | KDM4E (0.43) | KDM4EHPGDUSP2HSD17B10ALDH1A1 | |
| SCHEMBL19764239 | 0.70 | KDM4E (0.53) | KDM4EHPGDUSP2HSD17B10ALDH1A1 | |
| SCHEMBL17935315 | 0.69 | KDM4E (0.56) | KDM4EHPGDUSP2HSD17B10ALDH1A1 | |
| SCHEMBL21074873 | 0.69 | KDM4E (0.56) | KDM4EHPGDUSP2HSD17B10ALDH1A1 | |
| Emoxypine SCHEMBL29362452 | 0.68 | KDM4E (0.72) | KDM4EHPGDUSP2HSD17B10ALDH1A1 | |
| Emoxypine SCHEMBL195347 | 0.68 | KDM4E (0.72) | KDM4EHPGDUSP2HSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10221202-B2 | Annelated phenoxyacetamides | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2019-03-05 | — | — | US | disclosed |
| US-20180002312-A1 | TETRA- AND PENTASUBSTITUTED BENZIMIDAZOLIUM COMPOUNDS USEFUL IN THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-01-04 | — | — | US | disclosed |
| US-20170313732-A1 | NOVEL ANNELATED PHENOXYACETAMIDES | BOEHRINGER INGELHEIM INT (DE) | 2017-11-02 | — | — | US | disclosed |
| US-20170313732-A1 | NOVEL ANNELATED PHENOXYACETAMIDES | BOEHRINGER INGELHEIM INT (DE) | 2017-11-02 | — | — | US | disclosed |
| US-20170050992-A1 | NOVEL ANNELATED PHENOXYACETAMIDES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-02-23 | — | — | US | disclosed |
| US-20170050992-A1 | NOVEL ANNELATED PHENOXYACETAMIDES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170313732-A1 | NOVEL ANNELATED PHENOXYACETAMIDES | EP300, NAT1, AADAC | KDM4E 1618/4885HPGD 1680/4885USP2 2669/4885 |
| US-20180002312-A1 | TETRA- AND PENTASUBSTITUTED BENZIMIDAZOLIUM COMPOUNDS USEFUL IN THE TREATMENT OF RESPIRATORY DISEASES | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, F12, HRH4 | KDM4E 4220/4885HPGD 2958/4885USP2 3671/4885 |
| US-10221202-B2 | Annelated phenoxyacetamides | EP300, NAT1, REN | KDM4E 1513/4885HPGD 2239/4885USP2 3265/4885 |
| US-20170050992-A1 | NOVEL ANNELATED PHENOXYACETAMIDES | EP300, NAT1, AADAC | KDM4E 1567/4885HPGD 2350/4885USP2 2825/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.