Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GRK6 | P43250 | 3/20 | 0.46 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18540012 | 0.92 | GRK6 (0.55) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL17779957 | 0.85 | CYP1A2 (0.47) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL18539855 | 0.84 | KDM4E (0.46) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL18539848 | 0.82 | KDM4E (0.36) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL14907940 | 0.80 | GRK6 (0.65) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL18539899 | 0.79 | MEN1 (0.40) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL18540594 | 0.78 | GRK6 (0.52) | MAPTALDH1A1SMN1; SMN2GRK6MAPK1 | |
| SCHEMBL17214914 | 0.78 | ALDH1A1 (0.39) | MAPTALDH1A1SMN1; SMN2GRK6LMNA | |
| SCHEMBL18539856 | 0.78 | MITF (0.36) | MEN1KMT2AALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL18539904 | 0.78 | POLB (0.44) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9902739-B2 | Small molecule inhibitors of G protein coupled receptor 6 kinases polypeptides | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2018-02-27 | — | — | US | disclosed |
| US-20170050979-A1 | SMALL MOLECULE INHIBITORS OF G PROTEIN COUPLED RECEPTOR 6 KINASES POLYPEPTIDES | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2017-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170050979-A1 | SMALL MOLECULE INHIBITORS OF G PROTEIN COUPLED RECEPTOR 6 KINASES POLYPEPTIDES | GRK6, GRK2, GRK3 | MAPT 4029/4885MEN1 2275/4885KMT2A 2569/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.