Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.38 |
| ▸ | GRK6 | P43250 | 5/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | CCNC | P24863 | 3/20 | 0.35 |
| ▸ | CDK8 | P49336 | 3/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.30 |
| ▸ | MITF | O75030 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17213066 | 0.93 | GRK6 (0.42) | PRKAB1PRKAG1PRKAA1GRK6AR | |
| SCHEMBL18540469 | 0.85 | PRKAG1 (0.36) | PRKAB1PRKAG1PRKAA1GRK6AR | |
| SCHEMBL17212979 | 0.78 | TYMP (0.40) | PRKAB1PRKAG1PRKAA1GRK6CCNC | |
| SCHEMBL18540477 | 0.78 | GRK6 (0.36) | GRK6ALDH1A1MEN1MAPTMAPK1 | |
| SCHEMBL18540486 | 0.77 | PRKAG1 (0.37) | PRKAB1PRKAG1PRKAA1ARCCNC | |
| SCHEMBL18539843 | 0.77 | PRKAG1 (0.39) | PRKAB1PRKAG1PRKAA1ARCCNC | |
| SCHEMBL18540480 | 0.76 | MAPT (0.33) | GRK6ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL18540468 | 0.76 | SERPINE1 (0.34) | GRK6ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL18540478 | 0.75 | MAPT (0.34) | GRK6ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL18540594 | 0.75 | GRK6 (0.52) | GRK6ALDH1A1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170050939-A1 | SMALL MOLECULE INHIBITORS OF G PROTEIN COUPLED RECEPTOR 6 KINASE POLYPEPTIDES | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2017-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170050939-A1 | SMALL MOLECULE INHIBITORS OF G PROTEIN COUPLED RECEPTOR 6 KINASE POLYPEPTIDES | GRK6, GRK2, GRK3 | PRKAB1 507/4885PRKAG1 320/4885PRKAA1 387/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.