Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.51 |
| ▸ | RAB9A | P51151 | 8/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | NPC1 | O15118 | 7/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | G6PD | P11413 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9213019 | 0.74 | SMN1; SMN2 (0.49) | SMN1; SMN2RAB9AALDH1A1NPC1TP53 | |
| SCHEMBL2437459 | 0.72 | — | — | |
| SCHEMBL1451543 | 0.71 | SMN1; SMN2 (0.68) | SMN1; SMN2RAB9AALDH1A1NPC1TP53 | |
| SCHEMBL2440995 | 0.70 | — | — | |
| SCHEMBL1106504 | 0.69 | SMN1; SMN2 (0.41) | SMN1; SMN2RAB9AALDH1A1NPC1TP53 | |
| SCHEMBL14012701 | 0.69 | SMN1; SMN2 (0.45) | SMN1; SMN2RAB9AALDH1A1NPC1TP53 | |
| SCHEMBL11871419 | 0.69 | LMNA (0.49) | SMN1; SMN2RAB9AALDH1A1NPC1TP53 | |
| SCHEMBL8042854 | 0.68 | — | — | |
| SCHEMBL15331254 | 0.68 | SMN1; SMN2 (0.40) | SMN1; SMN2RAB9AALDH1A1NPC1TP53 | |
| SCHEMBL2442388 | 0.68 | SMN1; SMN2 (0.41) | SMN1; SMN2RAB9AALDH1A1NPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017029498-A1 | 2-SULFONYLPYRIMIDINES | MEDICAL RESEARCH COUNCIL (GB) | 2017-02-23 | — | — | WO | disclosed |