Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 15/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 12/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1859648 | 0.83 | CHRNA3 (0.57) | — | |
| SCHEMBL16150892 | 0.80 | MEN1 (0.48) | MEN1LMNAMAPTHPGDHTT | |
| SCHEMBL1852946 | 0.78 | HDAC1 (0.53) | HDAC1HDAC2HDAC8HDAC6HDAC3 | |
| SCHEMBL2055601 | 0.78 | KCNH2 (0.53) | — | |
| SCHEMBL16151050 | 0.73 | MAPT (0.42) | HDAC1HDAC2HDAC8HDAC3HDAC10 | |
| SCHEMBL21805191 | 0.73 | GAA (0.62) | HDAC1HDAC2HDAC8HDAC6HDAC3 | |
| SCHEMBL30087930 | 0.73 | GAA (0.62) | HDAC1HDAC2HDAC8HDAC6HDAC3 | |
| SCHEMBL14922960 | 0.72 | HDAC1 (0.44) | HDAC1HDAC2HDAC8HDAC6HDAC3 | |
| SCHEMBL2055612 | 0.71 | ALDH1A1 (0.52) | — | |
| SCHEMBL2055616 | 0.71 | ALDH1A1 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163729-B2 | Modulators of α7 nicotinic acetylcholine receptors and therapeutic uses thereof | WYETH (US) | 2012-04-24 | — | — | US | disclosed |
| EP-2323988-A1 | ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITORS | Wyeth LLC (US) | 2011-05-25 | — | — | EP | disclosed |