Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.45 |
| ▸ | MAOB | P27338 | 3/20 | 0.45 |
| ▸ | PARP15 | Q460N3 | 6/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 6/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ATF4 | P18848 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 5/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9948059 | 0.81 | MAOA (0.49) | MAOAMAOBPARP15PARP10BRD4 | |
| SCHEMBL20451538 | 0.81 | MAOA (0.49) | MAOAMAOBPARP15PARP10BRD4 | |
| SCHEMBL9948566 | 0.81 | MAOA (0.49) | MAOAMAOBPARP15PARP10BRD4 | |
| SCHEMBL9948565 | 0.81 | MAOA (0.49) | MAOAMAOBPARP15PARP10BRD4 | |
| SCHEMBL9948476 | 0.80 | BACE1 (0.52) | MAOAMAOBBACE1APP | |
| SCHEMBL9948474 | 0.80 | BACE1 (0.52) | MAOAMAOBBACE1APP | |
| SCHEMBL7887738 | 0.74 | BACE1 (0.52) | BACE1APP | |
| SCHEMBL16622125 | 0.70 | BACE1 (0.40) | MAOAMAOBPARP15PARP10PDK2 | |
| SCHEMBL16622126 | 0.68 | BACE1 (0.39) | MAOAMAOBPDK2BACE1APP | |
| SCHEMBL16622124 | 0.68 | BACE1 (0.54) | BACE1APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655378-B1 | COMPOUNDS AND THEIR USE AS BACE INHIBITORS | ASTRAZENECA AB (SE) | 2017-03-01 | — | — | EP | disclosed |