SCHEMBL18544005

SCHEMBL18544005

CC(CC(C)=Nc1c(C)cc(C)cc1C)=Nc1c(C)cc(C)cc1C

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAPGEF4 Q8WZA2 4/20 0.37
LMNA P02545 2/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
MMP1 P03956 1/20 0.33
MMP2 P08253 1/20 0.33
MMP9 P14780 1/20 0.33
MMP8 P22894 1/20 0.33
MMP13 P45452 1/20 0.33
ALDH1A1 P00352 2/20 0.32
KDM4E B2RXH2 2/20 0.32
GAA P10253 1/20 0.32
MAPT P10636 1/20 0.32
F2 P00734 3/20 0.32
PRSS1 P07477 3/20 0.32
PRSS2 P07478 3/20 0.32
PRSS3 P35030 3/20 0.32
TSHR P16473 1/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18544003 1.00 RAPGEF4 (0.37) RAPGEF4LMNACA1CA2MMP1
SCHEMBL14670497 1.00 RAPGEF4 (0.37) RAPGEF4LMNACA1CA2MMP1
SCHEMBL21192650 0.88 LMNA (0.41) LMNACA1CA2MMP1MMP2
SCHEMBL14792744 0.88 LMNA (0.41) LMNACA1CA2MMP1MMP2
SCHEMBL5799242 0.81 POLB (0.32)
SCHEMBL18544043 0.80 ATM (0.38) LMNAALDH1A1KDM4EMAPTMEN1
SCHEMBL18544044 0.80 ATM (0.38) LMNAALDH1A1KDM4EMAPTMEN1
SCHEMBL4090722 0.79 TDP1 (0.33) KDM4EMAPT
SCHEMBL4090725 0.79 TDP1 (0.33) KDM4EMAPT
SCHEMBL1513292 0.78 RAPGEF4 (0.36) RAPGEF4LMNACA1CA2MMP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115557985-B Method for selectively cracking C-S bond in thioether to form silane 成都泰蓉生物科技有限公司 2023-03-10 CN claimed
EP-3135697-B1 CATALYST COMPONENT FOR OLEFIN POLYMERIZATION AND CATALYST THEREOF CHINA PETROLEUM & CHEM CORP (CN) 2019-08-14 EP claimed
US-10208145-B2 Catalyst component for olefin polymerization, and catalyst containing the same CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2019-02-19 US claimed
US-20170073441-A1 Catalyst Component For Olefin Polymerization, and Catalyst Containing the Same CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2017-03-16 US claimed
EP-3135697-A1 CATALYST COMPONENT FOR OLEFIN POLYMERIZATION AND CATALYST THEREOF China Petroleum & Chemical Corporation (CN) 2017-03-01 EP claimed
CN-116023547-B Catalyst component, catalyst and method for olefin polymerization 中国石油化工股份有限公司 2024-08-06 CN disclosed
CN-115557985-B Method for selectively cracking C-S bond in thioether to form silane 成都泰蓉生物科技有限公司 2023-03-10 CN disclosed
EP-3135697-B1 CATALYST COMPONENT FOR OLEFIN POLYMERIZATION AND CATALYST THEREOF CHINA PETROLEUM & CHEM CORP (CN) 2019-08-14 EP disclosed
US-10208145-B2 Catalyst component for olefin polymerization, and catalyst containing the same CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2019-02-19 US disclosed
US-20170073441-A1 Catalyst Component For Olefin Polymerization, and Catalyst Containing the Same CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2017-03-16 US disclosed
EP-3135697-A1 CATALYST COMPONENT FOR OLEFIN POLYMERIZATION AND CATALYST THEREOF China Petroleum & Chemical Corporation (CN) 2017-03-01 EP disclosed